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Cat. No.: HY-122226

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IC-87361

IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC₅₀ of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma.

For research use only. We do not sell to patients.

CAS No.: 404011-02-5
Formula: C₁₉H₁₇NO₄
Molecular Weight:323.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IC-87361 Chemical Structure

CAS No.: 404011-02-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
C8166	EC₅₀	>200 μg/mL Compound: 5c	Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis	[PMID: 24794743]

In Vitro

IC-87361 selectively radiosensitises DNA-PK-competent wild-type endothelial cells, lung cancer cells, and melanoma cells, and enhances radiation-induced apoptosis in lung cancer and melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IC-87361 acts as a radiosensitizer to enhance ionizing radiation-induced tumour growth delay in human lung cancer xenografts, with a partial effect on tumour vasculature^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 404011-02-5
Molecular Weight 323.35
Formula C₁₉H₁₇NO₄
SMILES

O=C1C=C(OC2=CC(=CC(O)=C12)N3CCOCC3)C=4C=CC=CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Curtin N, et al. Therapeutic potential of drugs to modulate DNA repair in cancer. Expert Opin Ther Targets. 2007;11(6):783-799. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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