2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis
  3. DNA-PK Apoptosis
  4. IC-87361

IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC50 of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma.

For research use only. We do not sell to patients.

IC-87361

IC-87361 Chemical Structure

CAS No. : 404011-02-5

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IC-87361 Related Antibodies

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Description

IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC50 of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma[1].

Cellular Effect
Cell Line Type Value Description References
C8166 CC50
>200 μg/mL
Compound: 5c
Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 24794743]
C8166 CC50
200 μg/mL
Compound: 5c
Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 24794743]
C8166 EC50
>200 μg/mL
Compound: 5c
Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis
Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis
[PMID: 24794743]
In Vitro

IC-87361 selectively radiosensitises DNA-PK-competent wild-type endothelial cells, lung cancer cells, and melanoma cells, and enhances radiation-induced apoptosis in lung cancer and melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IC-87361 Related Antibodies
In Vivo

IC-87361 acts as a radiosensitizer to enhance ionizing radiation-induced tumour growth delay in human lung cancer xenografts, with a partial effect on tumour vasculature[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

323.35

Formula

C19H17NO4
CAS No.
SMILES

O=C1C=C(OC2=CC(=CC(O)=C12)N3CCOCC3)C=4C=CC=CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IC-87361 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IC-87361404011-02-5IC87361IC 87361DNA-PKApoptosisDNA-dependent protein kinaseDNA-dependent protein kinase (DNA-PKcs)lung cancer xenograftslung cancer cellsmelanoma cellsmelanomanon-homologous end joining (NHEJ)apoptosislung cancerwild-type endothelial cellsDNA double-strand break repairInhibitorinhibitorinhibit

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