404011-02-5
404011-02-5
Chemical Structure
IC-87361
- CAS No.: 404011-02-5
- Formula:C19H17NO4
- Molecular Weight:323.35
IUPAC Name: 5-hydroxy-7-morpholino-2-phenyl-4H-chromen-4-one
InChIKey: QLCYMYHLQRGYAZ-UHFFFAOYSA-N
SMILES: O=C1C=C(OC2=CC(=CC(O)=C12)N3CCOCC3)C=4C=CC=CC4
Biological Activity: IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC50 of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma[1].
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IC-87361 | IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC50 of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma. | |||||||||||||||||||||
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References
Keywords
