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Furostanol Saponins

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By Targets:	Drug Derivative (2) Drug Intermediate (1) NO Synthase (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4271

Protogracillin	Others	Cardiovascular Disease
Protogracillin is a steroidal furostanol saponin. Protogracillin can be isolated from the rhizomes and tubers of Dioscorea zingiberensis C.H. Wright. Protogracillin is hydrolyzable to Prosapogenin A (HY-N6940). Protogracillin exhibits antithrombotic activity. Protogracillin can be used in research related to cardiovascular diseases .

HY-N12148

Macrostemonoside I	Others	Others
Macrostemonoside I is a furostanol saponin that can be isolated from Allium macrostemon .

HY-N13136

Timosaponin D	Others	Cancer
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

HY-N18327

Terrestrosin F	Drug Derivative	Others
Terrestrosin F is a furostanol saponin found in the fruits of Tribulus terrestris .

HY-N12139

Nitric oxide production-IN-1	NO Synthase	Cancer
Nitric oxide production-IN-1（Compound 1） is a inhibitor of NO Production which isolated from Tupistra chinensis. Nitric oxide production-IN-1（Compound 1） inhibits NO production in rat abdomen macrophages induced by lipopolysaccharide

HY-N18263

(25R)-Timosaponin BII	Others	Others
(25R)-Timosaponin BII (Compound 7) is a furostanol saponin. (25R)-Timosaponin BII can be isolated from Anemarrhenae rhizoma .

HY-N19118

Ceparoside C	Drug Intermediate	Others
Ceparoside C is a steroidal saponin found in the seeds of Allium cepa L. Ceparoside C contains a furostanol aglycone (3β,26-dihydroxyfurosta-5,20(22)-diene) and a galactose sugar unit.

HY-N17753

Protoneodioscin NSC-698789	Others	Cancer
Protoneodioscin is a furostanol saponin found in the rhizomes of Dioscorea collettii var. hypoglauca. It exhibits selective activity against various cancer cell lines, including leukemia, but shows no activity against colon and renal cancer cells. Protoneodioscin can be used in research on cancers such as leukemia .

HY-N18108

Macrostemonoside F	Drug Derivative	Others
Macrostemonoside F is a Furostanol derivative. Macrostemonoside F can be isolated from the rhizomes of Yucca gloriosa L .

Protogracillin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Others
Protogracillin is a steroidal furostanol saponin. Protogracillin can be isolated from the rhizomes and tubers of Dioscorea zingiberensis C.H. Wright. Protogracillin is hydrolyzable to Prosapogenin A (HY-N6940). Protogracillin exhibits antithrombotic activity. Protogracillin can be used in research related to cardiovascular diseases .

Macrostemonoside I	Structural Classification Allium macrostemon Bunge Plants Amaryllidaceae Steroids Source Classification	Others
Macrostemonoside I is a furostanol saponin that can be isolated from Allium macrostemon .

Timosaponin D	Triterpenes Liliaceae Terpenoids Anemarrhena asphodeloides Bunge Plants Source Classification	Others
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

Terrestrosin F	Tribulus terrester Linn. Structural Classification Natural Products Zygophyllaceae Plants Source Classification	Drug Derivative
Terrestrosin F is a furostanol saponin found in the fruits of Tribulus terrestris .

Nitric oxide production-IN-1	Plants Rohdea chinensis (Baker) N.Tanaka Saccharides Monosaccharides Source Classification Asparagaceae Juss.	NO Synthase
Nitric oxide production-IN-1（Compound 1） is a inhibitor of NO Production which isolated from Tupistra chinensis. Nitric oxide production-IN-1（Compound 1） inhibits NO production in rat abdomen macrophages induced by lipopolysaccharide

(25R)-Timosaponin BII	Structural Classification Liliaceae Anemarrhena asphodeloides Bunge Plants Steroids Source Classification	Others
(25R)-Timosaponin BII (Compound 7) is a furostanol saponin. (25R)-Timosaponin BII can be isolated from Anemarrhenae rhizoma .

Ceparoside C	Structural Classification Liliaceae Allium cepa L. Plants Steroids Source Classification	Drug Intermediate
Ceparoside C is a steroidal saponin found in the seeds of Allium cepa L. Ceparoside C contains a furostanol aglycone (3β,26-dihydroxyfurosta-5,20(22)-diene) and a galactose sugar unit.

Protoneodioscin NSC-698789	Triterpenes Structural Classification Dioscorea collettii var. hypoglauca (Palib.) C. Pei & C. T. Ting Terpenoids Plants Dioscoreaceae Source Classification	Others
Protoneodioscin is a furostanol saponin found in the rhizomes of Dioscorea collettii var. hypoglauca. It exhibits selective activity against various cancer cell lines, including leukemia, but shows no activity against colon and renal cancer cells. Protoneodioscin can be used in research on cancers such as leukemia .

Macrostemonoside F	Structural Classification Yucca gloriosa L. Plants Steroids Asparagaceae Juss. Source Classification	Drug Derivative
Macrostemonoside F is a Furostanol derivative. Macrostemonoside F can be isolated from the rhizomes of Yucca gloriosa L .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Furostanol Saponins

Inhibitors & Agonists

NaturalProducts

Natural
Products