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G6PD

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By Targets:	Apoptosis (3) Autophagy (2) Mitophagy (2) Parasite (1) PDI (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Infection (1) Inflammation/Immunology (5) Metabolic Disease (3)

8

Inhibitors & Agonists

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Natural
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1

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

G6PD activator AG1 1 Publications Verification	Others	Metabolic Disease
G6PD activator AG1 is a potent and selective **glucose-6-phosphate dehydrogenase (G6PD) activator with an EC₅₀** of 3 µΜ . G6PD activator AG1 reduces hemolysis of human erythrocytes .

G6PDi-1	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive **glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀** of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

Fluasterone	Others	Metabolic Disease Inflammation/Immunology Cancer
Fluasterone is a potent *G6PD* inhibitor with a K_i of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active .

Polydatin Maximum Cited Publications 10 Publications Verification Piceid	Autophagy Apoptosis Mitophagy	Inflammation/Immunology Cancer
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

G6PD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PD Human Pre-designed siRNA Set A contains three designed siRNAs for G6PD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PD Human Pre-designed siRNA Set A G6PD Human Pre-designed siRNA Set A

Polydatin (Standard) Maximum Cited Publications 10 Publications Verification Piceid (Standard)	Autophagy Apoptosis Mitophagy	Inflammation/Immunology Cancer
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

6-Aminonicotinamide 4 Publications Verification	Others	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme **glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i**=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells .

RRx-001 5+ Cited Publications	Apoptosis Parasite	Infection Inflammation/Immunology Cancer
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α . RRx-001 is a potent inhibitor of *G6PD* and shows potent antimalarial activity .

Cat. No.	Compare	Product Name	Species	Source

	G6PD Protein, Human (HEK293, His) rHuGlucose-6-phosphate 1-dehydrogenase/G6PD, His; Glucose-6-Phosphate 1-Dehydrogenase; G6PD	Human	HEK293
	G6PD proteins play a key role in cellular metabolism by catalyzing the rate-limiting step of the oxidative pentose phosphate pathway, which is essential for carbohydrate dissimilation during glycolysis. The primary function of this enzyme is to provide reducing power in the form of NADPH and generate pentose phosphate, supporting essential processes such as fatty acid and nucleic acid synthesis. G6PD Protein, Human (HEK293, His) is the recombinant human-derived G6PD protein, expressed by HEK293 , with C-6*His labeled tag. The total length of G6PD Protein, Human (HEK293, His) is 514 a.a., with molecular weight of 55-62 kDa.

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