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GBP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Pim (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12929

NSC756093 SU093	Pim Apoptosis	Cancer
NSC756093 (SU093) is a *GBP1:PIM1* interaction inhibitor. NSC756093 binds to GBP1-PIM1 with a K_d of 38 nM. NSC756093 suppresses proliferation, reduces migration, induces G1 phase cell-cycle arrest, and increases apoptotic cell death in ovarian cancer cells. NSC756093 reduces cellular proteasomal activity, induces accumulation of ubiquitinated proteins, and restrains tumor progression and lung metastasis in murine ovarian cancer xenograft models. NSC756093 increases sensitivity of prostate cancer cells to Docetaxel (HY-B0011) and sensitizes GBP1-overexpressing ovarian cancer cells to Paclitaxel (HY-B0015). NSC756093 can be used for the research of prostate cancer and ovarian cancer ^[1] .

HY-RS05307

GBP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GBP1 Human Pre-designed siRNA Set A contains three designed siRNAs for GBP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GBP1 Human Pre-designed siRNA Set A GBP1 Human Pre-designed siRNA Set A

HY-RS24149

Gbp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gbp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gbp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gbp1 Rat Pre-designed siRNA Set A Gbp1 Rat Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75172

	GBP1 Protein, Human (HEK293, His) Guanylate-binding protein 1; GBP-1; HuGBP-1	Human	HEK293
	GBP1 Protein belongs to the dynamin superfamily of large GTPases. GBP1 plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. It hydrolyzes GTP to GMP in two consecutive cleavage reactions. GBP1 also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. In addition, it exhibits antiviral activity against influenza virus. GBP1 Protein, Human (HEK293, His) is the recombinant human-derived GBP1 protein, expressed by HEK293 , with C-10*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2) IHC-F (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P83185

	GBP1 Antibody (YA2930) GTP-binding protein 1	WB, IHC-F, IHC-P, ICC/IF	Human
	GBP1 Antibody (YA2930) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GBP1.

HY-P83185A

	GBP1 Antibody (YA2930)(PBS only) GTP-binding protein 1	WB, IHC-F, IHC-P, ICC/IF	Human
	GBP1 Antibody (YA2930) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GBP1.

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GBP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GBP1 Human Pre-designed siRNA Set A contains three designed siRNAs for GBP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gbp1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gbp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gbp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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