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Results for "

Grp94+Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (7)
By Research Areas:	Cancer (5) Inflammation/Immunology (1) Metabolic Disease (1)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112910

Grp94 Inhibitor-1 4 Publications Verification	HSP	Inflammation/Immunology Cancer
Grp94 Inhibitor-1 is a potent, selective *Grp94* inhibitor with an IC₅₀ value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α .

HY-18680

PU-WS13 3 Publications Verification	HSP	Cancer
PU-WS13 is a selective *Grp94* inhibitor, with an EC₅₀ of 0.22 μM.

HY-170818

Grp94 Inhibitor-3	HSP	Cancer
Grp94 Inhibitor-3 (Compound C6) is a selective glucose regulated protein 94 (Grp94) inhibitor with an affinity of 5.52 μM. Grp94 Inhibitor-3 is promising for research of primary open-angle glaucoma and metastatic cancer .

HY-162768

Grp94 Inhibitor-2	HSP	Cancer
Grp94 Inhibitor-2 (compound 23), a cyclopropane analog, exhibits high affinity for glucose-regulated protein 94 (Grp94) with a K_d of 0.48 µM and 0.65 µM for Grp94 and Hsp90α, respectively .

HY-120800

KUNG29	HSP	Metabolic Disease
KUNG29 is a potent and selective *Grp94* inhibitor with a Kd of 0.2 μM. KUNG29 induces the degradation of integrin α2 in MDA-MB-231 cells .

HY-103063

Iso-PU-H54	HSP	Others
Iso-PU-H54 is a purine-scaffold *Grp94* inhibitor with an IC₅₀ of 1.63 μM .

HY-121723

PU-H39	HSP	Cancer
PU-H39 (compound 9g) is a selective *Grp94* inhibitor with an IC₅₀ of 0.12 μM. PU-H39 exhibits 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively at 10 μM. PU-H39 can be used for the research of breast cancer .

Cat. No.	Product Name		Classification

HY-103063

Iso-PU-H54		Alkynes
Iso-PU-H54 is a purine-scaffold *Grp94* inhibitor with an IC₅₀ of 1.63 μM .

HY-121723

PU-H39		Alkynes
PU-H39 (compound 9g) is a selective *Grp94* inhibitor with an IC₅₀ of 0.12 μM. PU-H39 exhibits 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively at 10 μM. PU-H39 can be used for the research of breast cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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