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Cat. No.: HY-121723

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PU-H39

PU-H39 is a selective Grp94 inhibitor with an IC₅₀ of 0.12 μM. PU-H39 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

CAS No.: 852030-38-7
Formula: C₁₆H₁₃Cl₂N₅S
Molecular Weight:378.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PU-H39 Chemical Structure

CAS No.: 852030-38-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PU-H39 is a selective Grp94 inhibitor with an IC₅₀ of 0.12 μM. PU-H39 can be used for the research of breast cancer^[1].

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	>500 μM Compound: 11l	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]
SK-BR-3	IC₅₀	500 μM Compound: 11l	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]

In Vitro

PU-H39 (compound 9g) shows minimal off-target binding to kinases at 10 μM, exhibiting 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 852030-38-7
Molecular Weight 378.28
Formula C₁₆H₁₃Cl₂N₅S
SMILES

ClC1=CC=C(SC2=NC=3C(=NC=NC3N2CCCC#C)N)C(Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patel HJ, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015;58(9):3922-3943. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PU-H39

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PU-H39 Related Classifications

HY-121723 Related Classifications