2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. PU-H39

PU-H39 (compound 9g) is a selective Grp94 inhibitor with an IC50 of 0.12 μM. PU-H39 exhibits 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively at 10 μM. PU-H39 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

PU-H39

PU-H39 Chemical Structure

CAS No. : 852030-38-7

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PU-H39 Related Antibodies

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Description

PU-H39 (compound 9g) is a selective Grp94 inhibitor with an IC50 of 0.12 μM. PU-H39 exhibits 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively at 10 μM. PU-H39 can be used for the research of breast cancer[1].

In Vitro

PU-H39 (compound 9g) (0.12 μM (Grp94), >300 μM (Hsp90α/β), 145.4 μM (Trap-1); 24 h at 4 °C) potently and selectively inhibits Grp94 with an IC50 of 0.12 μM[1].
PU-H39 (compound 9g) (10 μM; 1 h incubation, 30 min elution) shows minimal off-target binding to kinases at 10 μM, with only weak inhibition of MKNK2 and ROCK2 observed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PU-H39 Related Antibodies
Molecular Weight

378.28

Formula

C16H13Cl2N5S
CAS No.
SMILES

ClC1=CC=C(SC2=NC=3C(=NC=NC3N2CCCC#C)N)C(Cl)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PU-H39 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PU-H39852030-38-7HSPHeat shock proteinsHsp90βROCK2Grp94MKNK2Hsp90αbreast cancerTrap-1Inhibitorinhibitorinhibit

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