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Art. -Nr.: HY-103063

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Iso-PU-H54

Iso-PU-H54 is a purine-scaffold Grp94 inhibitor with an IC₅₀ of 1.63 μM.

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CAS. Nr.: 852030-37-6
Formel: C₁₈H₁₉N₅S
Molecular Weight:337.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Iso-PU-H54 Chemical Structure

CAS. Nr.: 852030-37-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Iso-PU-H54 is a purine-scaffold Grp94 inhibitor with an IC₅₀ of 1.63 μM^[1].

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	31.8 μM Compound: 11k	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]

In Vitro

Iso-PU-H54 (compound 9i) inhibits recombinant Trap-1 with an IC₅₀ of 13.8 μM and shows no significant activity against recombinant Hsp90α or Hsp90β (IC₅₀ > 300 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 852030-37-6
Molecular Weight 337.45
Formel C₁₈H₁₉N₅S
SMILES

C#CCCCN1C(=NC=2C(=NC=NC21)N)SC3=CC=C(C=C3C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Patel HJ, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015;58(9):3922-3943. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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Iso-PU-H54

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Iso-PU-H54 Related Classifications

HY-103063 Related Classifications