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HaloPROTACs

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135306
    Cl-C6-PEG4-C3-COOH

    		PROTAC Linkers Cancer
    Cl-C6-PEG4-C3-COOH is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs) .
    Cl-C6-PEG4-C3-COOH
  • HY-145752
    HaloPROTAC-E
    1 Publications Verification

    		 SGK Autophagy Cancer
    HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14).
    <em>HaloPROTAC</em>-E
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH

    PROTAC Linker 4

    		 PROTAC Linkers Cancer
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs) .
    Cl-C6-PEG4-O-CH2COOH
  • HY-151227
    VL285 Phenol

    		Others Cancer
    VL285 Phenol is a VL285 analogue with Phenol group. VL285, a small molecule VHL ligand, can be served as a degrader for HaloPROTAC3 synthesis.VL285 degrades HaloTag7 fusion proteins (IC50=0.34 μM) .
    VL285 Phenol
  • HY-103608
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl

    VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .
    (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
  • HY-112495
    VH032-PEG5-C6-Cl

    HaloPROTAC 2

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and 21-atom-length linker. The connector of linker is Halogen group. VH032-PEG5-C6-Cl incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .
    VH032-PEG5-C6-Cl
  • HY-111997
    VH285-PEG4-C4-Cl

    HaloPROTAC 3

    		 E3 Ligase Ligand-Linker Conjugates
    VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM .
    VH285-PEG4-C4-Cl

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