2. PROTAC
  3. PROTAC Linkers
  4. Cl-C6-PEG4-C3-COOH

Cl-C6-PEG4-C3-COOH is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).

For research use only. We do not sell to patients.

Cl-C6-PEG4-C3-COOH Chemical Structure

Cl-C6-PEG4-C3-COOH Chemical Structure

CAS No. : 2127391-58-4

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5 mg USD 210 In-stock
10 mg USD 340 In-stock
25 mg USD 680 In-stock
50 mg USD 1100 In-stock
100 mg USD 1760 In-stock
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Based on 1 publication(s) in Google Scholar

Cl-C6-PEG4-C3-COOH Related Antibodies

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Description

Cl-C6-PEG4-C3-COOH is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs)[1].

IC50 & Target[1]

PEGs

 

Molecular Weight

382.92

Formula

C18H35ClO6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCCCCOCCOCCOCCOCCCCCCCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (261.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6115 mL 13.0576 mL 26.1151 mL
5 mM 0.5223 mL 2.6115 mL 5.2230 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

COA (239 KB) HNMR (136 KB) RP-HPLC (219 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6115 mL 13.0576 mL 26.1151 mL 65.2878 mL
5 mM 0.5223 mL 2.6115 mL 5.2230 mL 13.0576 mL
10 mM 0.2612 mL 1.3058 mL 2.6115 mL 6.5288 mL
15 mM 0.1741 mL 0.8705 mL 1.7410 mL 4.3525 mL
20 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2644 mL
25 mM 0.1045 mL 0.5223 mL 1.0446 mL 2.6115 mL
30 mM 0.0871 mL 0.4353 mL 0.8705 mL 2.1763 mL
40 mM 0.0653 mL 0.3264 mL 0.6529 mL 1.6322 mL
50 mM 0.0522 mL 0.2612 mL 0.5223 mL 1.3058 mL
60 mM 0.0435 mL 0.2176 mL 0.4353 mL 1.0881 mL
80 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8161 mL
100 mM 0.0261 mL 0.1306 mL 0.2612 mL 0.6529 mL
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Cl-C6-PEG4-C3-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-C6-PEG4-C3-COOH2127391-58-4PROTAC Linkerssynthesischloroalkane-containingPROTACsHaloPROTACsInhibitorinhibitorinhibit

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