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Results for "

IETD

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

3

Fluorescent Dyes

14

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101297
    Z-IETD-FMK
    65+ Cited Publications

    Z-IE(OMe)TD(OMe)-FMK

    		 Caspase Cancer
    Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .
    Z-IETD-FMK
  • HY-P1169
    Ac-IETD-AFC
    1 Publications Verification

    		 Caspase Others
    Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
    Ac-IETD-AFC
  • HY-113963
    Ac-​IETD-​CHO

    		Apoptosis Cancer
    Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death .
    Ac-​IETD-​CHO
  • HY-P2208
    Z-IETD-AFC

    		Fluorescent Dye Cancer
    Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .
    Z-IETD-AFC
  • HY-P4222
    IETD-CHO

    Caspase-8-IN-1

    		 Caspase Others
    IETD-CHO (Caspase-8-IN-1) is a potent caspase-8 inhibitor .
    IETD-CHO
  • HY-120833
    Ac-Ile-Glu-Thr-Asp-pNA

    		Caspase Others
    Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
    Ac-Ile-Glu-Thr-Asp-pNA
  • HY-P10322
    Z-IETD-R110

    		Fluorescent Dye Cancer
    Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .
    Z-IETD-R110
  • HY-P1169A
    Ac-IETD-AFC TFA

    		Caspase Others
    Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin). When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm; Em = ~505 nm) .
    Ac-IETD-AFC TFA
  • HY-P10001
    Z-IETD-pNA

    Z-Ile-Glu-Thr-Asp-pNA

    		 Caspase Cancer
    Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .
    Z-IETD-pNA
  • HY-P3362
    Ac-IETD-AMC

    		Fluorescent Dye Others
    Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
    Ac-IETD-AMC
  • HY-P4222A
    IETD-CHO TFA

    		Caspase Others
    IETD-CHO TFA (Caspase-8-IN-1) is a potent caspase-8 inhibitor .
    IETD-CHO TFA
  • HY-P10454
    (Z-IETD)2-Rh 110

    (Z-Ile-Glu-Thr-Asp)2-R110

    		 Caspase Others
    (Z-IETD)2-Rh 110 is a fluorescent substrate of caspase-8 (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of caspase-8 and the process of apoptosis .
    (Z-IETD)2-Rh 110
  • HY-175057
    Ac-IETD-CHO TFA

    		Apoptosis Inflammation/Immunology Cancer
    Ac-IETD-CHO TFA is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-IETD-CHO TFA inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-IETD-CHO TFA also inhibits cytotoxic T lymphocytes induced cell death .
    Ac-IETD-CHO TFA
  • HY-101297R
    Z-IETD-FMK (Standard)

    Z-IE(OMe)TD(OMe)-FMK (Standard)

    		 Caspase Reference Standards Cancer
    Z-IETD-FMK (Standard) is the analytical standard of Z-IETD-FMK (HY-101297). This product is intended for research and analytical applications. Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .
    Z-IETD-FMK (Standard)

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