Ac-IETD-AFC
Based on 1 publication(s) in Google Scholar
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B.
For research use only. We do not sell to patients.
- Purity: 99.28%
- CAS No.: 211990-57-7
- Formula: C31H38F3N5O12
- Molecular Weight:729.65
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ac-IETD-AFC
MoreAll Caspase Isoforms
More
Biological Activity
500
380
Chemical Information
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CAS No. 211990-57-7
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Appearance Solid
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Molecular Weight 729.65
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Formula C31H38F3N5O12
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Genes (Basel)
Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber Apostichopus japonicus. [Abstract]2024 Apr 25;15(5):540. PMID: 38790170
Solvent & Solubility
DMSO : 125 mg/mL (171.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. [1]Kazimierz Weglarczyk, et al. Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus. Infect Immun. 2004 May;72(5):2590-7. [Content Brief]
[2]. Przemysław Reszka, et al. Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem. 2010 Jan;5(1):103-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3705 mL | 6.8526 mL | 13.7052 mL | 34.2630 mL |
| 5 mM | 0.2741 mL | 1.3705 mL | 2.7410 mL | 6.8526 mL | |
| 10 mM | 0.1371 mL | 0.6853 mL | 1.3705 mL | 3.4263 mL | |
| 15 mM | 0.0914 mL | 0.4568 mL | 0.9137 mL | 2.2842 mL | |
| 20 mM | 0.0685 mL | 0.3426 mL | 0.6853 mL | 1.7132 mL | |
| 25 mM | 0.0548 mL | 0.2741 mL | 0.5482 mL | 1.3705 mL | |
| 30 mM | 0.0457 mL | 0.2284 mL | 0.4568 mL | 1.1421 mL | |
| 40 mM | 0.0343 mL | 0.1713 mL | 0.3426 mL | 0.8566 mL | |
| 50 mM | 0.0274 mL | 0.1371 mL | 0.2741 mL | 0.6853 mL | |
| 60 mM | 0.0228 mL | 0.1142 mL | 0.2284 mL | 0.5711 mL | |
| 80 mM | 0.0171 mL | 0.0857 mL | 0.1713 mL | 0.4283 mL | |
| 100 mM | 0.0137 mL | 0.0685 mL | 0.1371 mL | 0.3426 mL |
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