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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
KMT9
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "KMT9" in MCE Product Catalog:
Cat. No.: HY-157486
Purity: 98.00%
Target:
Research Areas:
KMI169 is a potent and selective inhibitor targeting lysine methyl-transferase (KMT9) (IC50 = 0.05 μM, Kd = 0.025 μM). KMI169 functions as a bi-substrate inhibitor targeting the cofactor S-5’-adenosyl-L-methionine (SAM) and substrate binding pockets of KMT9. KMI169 can downregulate target genes involved in cell cycle regulation and impair proliferation of tumor cells by inhibiting KMT9. KMI169 is a valuable tool to probe cellular KMT9 functions and can be research for combating diseases including prostate, lung, colon, and invasive bladder cancer .
Cat. No.: HY-174450
CAS No.: 2625406-61-1
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KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and the ethyl ester prodrug of compound 7b. KMT9-IN-1 releases the active form 7b via esterases in cells. KMT9-IN-1 targets KMT9 in cells and reduces H4K12me1 levels. KMT9-IN-1 has antitumor activity against colon cancer. KMT9-IN-1 can be used in the research of prostate cancer and hepatocellular carcinoma .
Cat. No.: HY-174451
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KMT9-IN-2 (Compound 7b) is an active form of a KMT9 inhibitor (Kd of 10 nM). KMT9-IN-2 can be used in the research of colon cancer .
Cat. No.: HY-P77376
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HEMK2; N-6 Adenine-Specific DNA Methyltransferase 1 (Putative); Prev. C21orf127; Methylarsonite Methyltransferase N6AMT1; Prev. N6AMT1; Lysine N-Methyltransferase 9; PRED28; Methyltransferase N6AMT1; KMT9; Methyltransferase HEMK2; HemK Methyltransferase F
Cat. No.: HY-RS08984
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Research Areas:
N6AMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for N6AMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703465
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TRMT112; AD-001; HSPC152; HSPC170; Multifunctional methyltransferase subunit TRM112-like protein; tRNA methyltransferase 112 homolog; TRM112; HTrm112; TRMT11-2; TRNA Methyltransferase Activator Subunit 11-2; TRM112-Like Protein; TRNA Methyltransferase 11-2 Homolog; TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae); TRNA Methyltransferase Subunit 11-2; HEMK2; N-6 Adenine-Specific DNA Methyltransferase 1 (Putative); Prev. C21orf127; Methylarsonite Methyltransferase N6AMT1; Prev. N6AMT1; Lysine N-Methyltransferase 9; PRED28; Methyltransferase N6AMT1; KMT9; Methyltransferase HEMK2; HemK Methyltransferase Family Member 2; M.HsaHemK2P; N6AMT; N-6 Adenine-Specific DNA Methyltransferase 1; MTQ2; Chromosome 21 Open Reading Frame 127; PrmC; N6-DNA-Methyltransferase; HemK Methyltransferase 2, ETF1 Glutamine And Histone H4 Lysine; Protein N(5)-Glutamine Methyltransferase
Cat. No.: HY-183602
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FRC-303 is a CHD1 inhibitor with a Kd of 0.14 μM and an IC50 of 0.18 μM. FRC-303 binds to the H3K4me3 binding site of CHD1 tandem chromodomain, forms aromatic cage interactions and extended ligand contacts, acts as a methyl-lysine mimic, and occupies natural peptide ligand-binding regions. FRC-303 can be used for the research of prostate cancer .
Cat. No.: HY-183603
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FRC-222 is a CHD1 tandem chromodomain inhibitor with a Kd of 0.15 μM and an IC50 of 0.18 μM. FRC-222 binds to the H3K4me3 binding site of CHD1 tandem chromodomain via aromatic cage interactions and extended ligand contacts. FRC-222 can be used for the research of prostate cancer[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
