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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

MRP1-overexpressing cells

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135336S
    (R)-Verapamil-d7 (hydrochloride)

    (R)-(+)-Verapamil-d7 (hydrochloride)

    		 P-glycoprotein Isotope-Labeled Compounds Apoptosis Cancer
    (R)-Verapamil-d7 (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .
    (R)-Verapamil-d7 (hydrochloride)
  • HY-W702292
    (R)-(+)-Verapamil-d6 hydrochloride

    		Isotope-Labeled Compounds Apoptosis P-glycoprotein Cancer
    (R)-(+)-Verapamil-d6 (hydrochloride) is deuterium labeled (R)-Verapamil (hydrochloride). (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .
    (R)-(+)-Verapamil-d6 hydrochloride
  • HY-136907
    (S)-Verapamil

    (S)-(-)-Verapamil

    		 P-glycoprotein Apoptosis Cardiovascular Disease Cancer
    (S)-Verapamil ((S)-(-)-Verapamil) is an orally active MRP1 (ABCC1) modulator with a Kd value of 113 nM for hamster MRP1. (S)-Verapamil regulates MRP1, promotes MRP1-mediated glutathione efflux and the transport of calcein and leukotriene C4, reverses glutathione-activated MRP1 ATPase activity, and ultimately depletes intracellular glutathione and induces cell death. (S)-Verapamil specifically induces apoptosis in MRP1-overexpressing tumor cells. (S)-Verapamil can be used in research related to cancer, cardiac diseases such as supraventricular arrhythmia, and hypertension .
    (S)-Verapamil
  • HY-118083
    Pentamethoxymorin

    MRS923

    		 BCRP Cancer
    Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer .
    Pentamethoxymorin

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