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Results for "

Methylthioadenosine phosphorylase (MTAP)

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-156680
    Vopimetostat

    TNG-462

    		 Histone Methyltransferase Cancer
    TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers .
    Vopimetostat
  • HY-101496
    MT-DADMe-ImmA
    4 Publications Verification

    MTDIA; Methylthio-DADMe-Immucillin A

    		 Histone Methyltransferase Cancer
    MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.
    MT-DADMe-ImmA
  • HY-16933
    L-Alanosine
    1 Publications Verification

    NSC-153353; SDX-102

    		 Antibiotic DNA/RNA Synthesis Infection Cancer
    L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP) .
    L-Alanosine
  • HY-W750643
    m-APTA

    5′-S-(3-Aminophenyl)-5′-thioadenosine

    		 Phosphorylase Cancer
    m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA). m-APTA is promising for research of MTAP-deficient cancers .
    m-APTA
  • HY-155148
    MAT2A-IN-11

    		Methionine Adenosyltransferase (MAT) Cancer
    MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with an IC50 of 6.8 nM .
    MAT2A-IN-11
  • HY-179622
    ZS34

    		Methionine Adenosyltransferase (MAT) Cancer
    ZS34 is a potent, orally active, and selective MAT2A inhibitor with an IC50 of 13.7 nM, displaying minimal hERG and UGT1A1 liabilities. ZS34 selectively suppresses the growth of methylthioadenosine phosphorylase (MTAP)-deficient cancer cells by inhibiting SAM synthesis, reducing SDMA levels, and inducing DNA damage. ZS34 exhibits antitumor efficacy in a HCT116 MTAP -/- xenograft mouse model. ZS34 can be used for the research of MTAP-deficient cancer .
    ZS34

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