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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
NB4 AML cells
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "NB4 AML cells" in MCE Product Catalog:
Cat. No.: HY-172399
Research Areas:
FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models .
Cat. No.: HY-W965550
CAS No.: 83800-90-2
Apoptosis inducer 40 is an apoptosis inducer. Apoptosis inducer 40 exhibits potent cytotoxic effects against jurkat and NB4 cells with IC50 values of 4.5 μM and 3.6μM. Apoptosis inducer 40 induces apoptosis and arrests cell cycle. Apoptosis inducer 40 can be used for the research of cancer, such as acute myeloid leukemia (AML) .
Cat. No.: HY-149522
CAS No.: 3034883-70-7
Target:
Research Areas:
BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively) .
Cat. No.: HY-184097
CAS No.: 3098670-37-9
MS9117 is a PROTAC molecule that targets and degrades LSD1/BHC110 by recruiting CRBN. MS9117 effectively increases the level of histone H3 lysine 4 monomethylation. MS9117 significantly inhibits the proliferation and colony formation of cancer cells, promotes their myeloid differentiation, and enhances the sensitivity of non-acute promyelocytic leukemia-type AML cells to all-trans retinoic acid (ATRA) .
Cat. No.: HY-184101
Research Areas:
CC-90011-COOH is a LSD1 ligand. CC-90011-COOH serves as a Ligand for Target Protein for PROTAC for the synthesis of LSD1 PROTAC degraders, such as MS9117 (HY-184097). CC-90011-COOH is applicable to the research of acute myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
