2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. WK499

BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively).

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WK499

WK499 Chemical Structure

CAS No. : 3034883-70-7

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WK499 Related Antibodies

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Description

BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively)[1].

Molecular Weight

498.33

Formula

C21H20BrN7O3
CAS No.
SMILES

O=C(O1)C=CC2=C1C=CC(NC3=CC(N4CCCC(NC(CBr)=O)C4)=NC5=NC=NN53)=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WK499 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WK4993034883-70-7WK 499WK-499Bcl-2 FamilyApoptosisAMLacute myeloid leukemiacancerDNA damageSMRTInhibitorinhibitorinhibit

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