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Cat. No.: HY-W965550

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Apoptosis inducer 40

Apoptosis inducer 40 is an apoptosis inducer. Apoptosis inducer 40 exhibits potent cytotoxic effects against jurkat and NB4 cells with IC₅₀ values of 4.5 μM and 3.6μM. Apoptosis inducer 40 induces apoptosis and arrests cell cycle. Apoptosis inducer 40 can be used for the research of cancer, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

CAS No.: 83800-90-2
Formula: C₁₄H₈Cl₂N₂O
Molecular Weight:291.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Apoptosis inducer 40 Chemical Structure

CAS No.: 83800-90-2

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Apoptosis inducer 40 (Compound 17) (0.8-50 μM, 24-72 h) time-dependently decreases cell viability in Jurkat and NB4 cells^[1].
Apoptosis inducer 40 (0.6-10 μM, 48 h) induces apoptosis in Jurkat and NB4 cells^[1].
Apoptosis inducer 40 (3.6-4.5 μM, 0-48 h) induces G0/G1 arrest in Jurkat cells and S phase arrest in NB4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

Jurkat and NB4 cells
Concentration:

4.5 μM in Jurkat and 3.6 μM in NB4 cells
Incubation Time:

0, 12 24 and 48 h
Result:

Caused an accumulation of G0/G1 in Jurkat cells.
Demonstrated a blocking effect in S phase in NB4 cells.

Chemical Information

CAS No. 83800-90-2
Molecular Weight 291.13
Formula C₁₄H₈Cl₂N₂O
SMILES

O=C1NC(C2=CC=CC(Cl)=C2Cl)=NC3=CC=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Antoniolli G, et al. Synthesis and Evaluation of 2‑Substituted Quinazolin-4(3H)‑ones as Potential Antileukemic Agents. ACS Omega. 2025 Aug 1;10(31):34882-34894. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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