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RIP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PROTACs (3) RIP kinase (10) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (1) Inflammation/Immunology (5)

11

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

RIP2 Kinase Inhibitor 3	RIP kinase	Inflammation/Immunology
RIP2 Kinase Inhibitor 3 is a highly potent and selective inhibitor of *receptor interacting protein-2 (RIP2) Kinase* with an IC₅₀ of 1 nM .

RIP2 kinase inhibitor 2 2 Publications Verification	RIP kinase	Cancer
RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.

RIP2 kinase inhibitor 1	RIP kinase	Inflammation/Immunology
RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC₅₀ of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders .

RIP2 Kinase Inhibitor 4	RIP kinase PROTACs	Inflammation/Immunology
RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC₅₀ of 8) and inhibits the release of related TNF-α .

RIPK2-IN-2	RIP kinase PROTACs	Infection
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases .

PROTAC RIPK degrader-6	PROTACs RIP kinase	Cancer
PROTAC RIPK degrader-6 (example 1) is a Cereblon-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder .

GSK583 5 Publications Verification	RIP kinase	Endocrinology
GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC₅₀ of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC₅₀ value of 200 nM.

GSK2983559	RIP kinase	Inflammation/Immunology
GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples .

GSK2983559 active metabolite 1 Publications Verification	RIP kinase	Cancer
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

GSK2983559 free acid	RIP kinase	Inflammation/Immunology
GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples .

RIPOR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RIPOR2 Human Pre-designed siRNA Set A contains three designed siRNAs for RIPOR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RIPOR2 Human Pre-designed siRNA Set A RIPOR2 Human Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source

	RIPK2 Protein, Human (P. pastoris, His) receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30	Human	P. pastoris
	RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6His, C-6His labeled tag. The total length of RIPK2 Protein, Human (P. pastoris, His) is 540 a.a., with molecular weight of 66 kDa.

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