1. PROTAC
    Apoptosis
  2. PROTAC
    RIP kinase
  3. PROTAC RIPK degrader-6

PROTAC RIPK degrader-6 

Cat. No.: HY-111870 Purity: 99.32%
Handling Instructions

PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder.

For research use only. We do not sell to patients.

PROTAC RIPK degrader-6 Chemical Structure

PROTAC RIPK degrader-6 Chemical Structure

CAS No. : 2089205-64-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 831 In-stock
Estimated Time of Arrival: December 31
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].

Molecular Weight

889.00

Formula

C₄₃H₄₈N₆O₁₁S₂

CAS No.

2089205-64-9

SMILES

O=S(C(C(OCCOCCOCCOCCOCC(NC1=C(CN(C2C(NC(CC2)=O)=O)C3=O)C3=CC=C1)=O)=C4)=CC(C4=NC=C5)=C5NC6=CC(N=CS7)=C7C=C6)(C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

PROTAC RIPK degrader-6PROTAC RIPK degrader6PROTAC RIPK degrader 6PROTACRIP kinaseProteolysis-targeting chimeraReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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Product Name:
PROTAC RIPK degrader-6
Cat. No.:
HY-111870
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