1. Apoptosis PROTAC
  2. RIP kinase PROTACs
  3. RIP2 Kinase Inhibitor 4

RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α.

For research use only. We do not sell to patients.

RIP2 Kinase Inhibitor 4 Chemical Structure

RIP2 Kinase Inhibitor 4 Chemical Structure

CAS No. : 2126803-41-4

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Description

RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1].

IC50 & Target[1]

cIAP1

 

RIPK2

8 (pIC50)

In Vitro

RIP2 Kinase Inhibitor 4 (Compound 20) utilizes a novel inhibitor of apoptosis (IAP) binder. RIP2 Kinase Inhibitor 4 possess comparatively reduced binding potency at both cIAP1 and XIAP BIR3 domains and increased potency at the XIAP BIR2 domain[1].
RIP2 Kinase Inhibitor 4 (Compound 20) recruits the IAP E3 ligases and shows markedly reduced inhibition of muramyl dipeptide (MDP)-stimulated TNFα production in human peripheral blood mononuclear cells (PBMCs) (pIC50 of 9.3)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The initial in vivo assessment of RIP2 Kinase Inhibitor 4 (Compound 20) in rats dosed at 0.5 mg/kg SC demonstrated high levels of RIPK2 degradation and inhibition of MDP-stimulated TNFα release at the final 48 h time point[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1045.21

Formula

C50H66F2N14O7S

CAS No.
SMILES

CC1=C(C)NN=C1NC2=NC=NC3=C2C=C(S(C(C)(C)C)(=O)=O)C(OCCCN4CCN(C5=NC=C(C(N[C@@H]6CN(C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)[C@H](C(NC(C(F)=CC=C7)=C7F)=O)C6)=O)N=C5)CC4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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RIP2 Kinase Inhibitor 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RIP2 Kinase Inhibitor 4
Cat. No.:
HY-136010
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