1. Apoptosis
    TGF-beta/Smad
  2. RIP kinase
    TGF-β Receptor
  3. OD36

OD36 

Cat. No.: HY-19628
Handling Instructions

OD36 is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with KDs of 37 nM.

For research use only. We do not sell to patients.

OD36 Chemical Structure

OD36 Chemical Structure

CAS No. : 1638644-62-8

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Description

OD36 is a RIPK2 inhibitor with an IC50 of 5.3 nM[2]. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with KDs of 37 nM[2].

IC50 & Target[1][2]

RIPK2

5.3 nM (IC50)

ALK2

37 nM (Kd)

ALK2

47 nM (IC50)

ALK2 R206H

22 nM (IC50)

In Vitro

OD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively[1].
OD36 shows activity against ALK1 with a KD of 90 nM[2].
OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation[2].
OD36 (0.1-1 μM) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells[2].
Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A[2].

Western Blot Analysis[2]

Cell Line: KS483 cells
Concentration: 0.1, 0.2, and 1 μM
Incubation Time:
Result: Inhibited BMP-6 induced p-Smad1/5.
Molecular Weight

330.77

Formula

C₁₆H₁₅ClN₄O₂

CAS No.

1638644-62-8

SMILES

ClC1=CC(C2=C3N/C(C=CN3N=C2)=N/CCOCCO4)=CC4=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

OD36OD 36OD-36RIP kinaseTGF-β ReceptorReceptor-interacting protein kinasesRIPKTransforming growth factor beta receptorsFibrodysplasiaossificansprogressivaFOPmacrocyclicALK2RIPK2Inhibitorinhibitorinhibit

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OD36
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HY-19628
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