BMP-6
Bone morphogenetic protein 6 (BMP-6) is a 57-kDa glycoprotein of the TGF-β superfamily that signals canonically through BMPR1A/ALK3 and BMPR2 to phosphorylate SMAD1/5/8, and occupies distinctive physiological niches beyond skeletal development. BMP-6 is the key hepatic iron regulator: it is produced by liver sinusoidal endothelial cells in response to iron loading and by hepatocytes, and acts on hepatocytes to induce hepcidin (HAMP) expression via SMAD1/5, thereby controlling systemic iron homeostasis; BMP-6 loss lowers hepcidin and promotes iron overload, a mechanism highly relevant to anemia of inflammation and hereditary hemochromatosis. In the nervous system, BMP-6 guides noradrenergic differentiation of neural crest and cholinergic differentiation in the basal forebrain. BMP-6 is also essential for follicular development and luteinization in the ovary, promotes osteoblast differentiation, and is silenced epigenetically in many cancers while acting pro-tumorically in gliomas and breast cancer stem-like populations.
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BMP-6 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
