1. Apoptosis
  2. RIP kinase
  3. RIP1 kinase inhibitor 1

RIP1 kinase inhibitor 1 

Cat. No.: HY-111409
Handling Instructions

RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04).

For research use only. We do not sell to patients.

RIP1 kinase inhibitor 1 Chemical Structure

RIP1 kinase inhibitor 1 Chemical Structure

CAS No. : 2095515-38-9

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Description

RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1].

IC50 & Target

pKi: 9.04 (RIP1 kinase)[1]

In Vitro

RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC50=15 nM; pMLKL, IC50=2.7 nM)[1].

Molecular Weight

461.90

Formula

C₂₄H₂₀ClN₅O₃

CAS No.

2095515-38-9

SMILES

N#CC1=CC=C2N(C)C([[email protected]@H](N3CCC4=C(Cl)N(CC5=CC=CC=C5)N=C4C3=O)COC2=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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RIP1 kinase inhibitor 1
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