2126803-41-4
Chemical Structure
RIP2 Kinase Inhibitor 4
- CAS No.: 2126803-41-4
- Formula:C50H66F2N14O7S
- Molecular Weight:1045.21
IUPAC Name: 5-(4-(3-((6-(tert-butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-N-((3S,5S)-5-((2,6-difluorophenyl)carbamoyl)-1-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidin-3-yl)pyrazine-2-carbo
InChIKey: CHNBEZLJAQUZEX-LFRONEFISA-N
SMILES: CC1=C(C)NN=C1NC2=NC=NC3=C2C=C(S(C(C)(C)C)(=O)=O)C(OCCCN4CCN(C5=NC=C(C(N[C@@H]6CN(C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)[C@H](C(NC(C(F)=CC=C7)=C7F)=O)C6)=O)N=C5)CC4)=C3
Biological Activity: RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1].
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RIP2 Kinase Inhibitor 4 | RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α. | |||||||||||||||||||||
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Keywords
