1. Apoptosis
  2. RIP kinase
  3. GSK'481

GSK'481 (Synonyms: GSK481)

Cat. No.: HY-100131 Purity: >98.0%
Handling Instructions

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.

For research use only. We do not sell to patients.

GSK'481 Chemical Structure

GSK'481 Chemical Structure

CAS No. : 1622849-58-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 91 In-stock
Estimated Time of Arrival: December 31
2 mg USD 65 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 590 In-stock
Estimated Time of Arrival: December 31
100 mg USD 990 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells GSK'481 have approximately equivalent RIP1 FP potencies against human and cynomolgus monkey RIP1 but was >100-fold less potent against nonprimate RIP1

Molecular Weight

377.39

Formula

C₂₁H₁₉N₃O₄

CAS No.

1622849-58-4

SMILES

O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[[email protected]]3COC4=CC=CC=C4N(C)C3=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (92.74 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6498 mL 13.2489 mL 26.4978 mL
5 mM 0.5300 mL 2.6498 mL 5.2996 mL
10 mM 0.2650 mL 1.3249 mL 2.6498 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
GSK'481
Cat. No.:
HY-100131
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