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Results for "

RSPO1

" in MedChemExpress (MCE) Product Catalog:

1

Inhibitors & Agonists

8

Recombinant Proteins

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Cat. No. Compare Product Name Species Source
  • HY-P700253AF
    Animal-Free RSPO1/R-spondin-1 Protein, Human (243a.a, HEK293, His, SUMO)

    R-spondin-1; Roof plate-specific spondin-1; RSPO1

    		 Human HEK293
    RSPO1 or R-spondin-1 activates the canonical Wnt pathway through ligand binding to the LGR4-6 receptor, forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction upregulates target gene expression. Animal-Free RSPO1/R-spondin-1 Protein, Human (243a.a, HEK293, His, SUMO) is the recombinant human-derived animal-FreeRSPO1/R-spondin-1 protein, expressed by HEK293 , with N-His, N-SUMO labeled tag. The total length of Animal-Free RSPO1/R-spondin-1 Protein, Human (243a.a, HEK293, His, SUMO) is 243 a.a., with molecular weight of ~65 kDa.
  • HY-P76012
    RSPO1/R-spondin-1 Protein, Mouse (CHO, His)

    R-spondin-1; Roof plate-specific spondin-1; RSPO1

    		 Mouse CHO
    RSPO1 activates the canonical Wnt signaling pathway by binding to the LGR4-6 receptor, triggering an increase in target gene expression. It inhibits ZNRF3, regulates the Wnt signaling pathway, and negatively regulates the TGF-β pathway. RSPO1/R-spondin-1 Protein, Mouse (CHO, His) is the recombinant mouse-derived RSPO1/R-spondin-1 protein, expressed by CHO , with C-His labeled tag. The total length of RSPO1/R-spondin-1 Protein, Mouse (CHO, His) is 245 a.a., with molecular weight of ~44 kDa.
  • HY-P72784
    RSPO1/R-spondin-1 Protein, Human (HEK293, His)
    1 Publications Verification

    R-spondin-1; Roof plate-specific spondin-1; RSPO1

    		 Human HEK293
    RSPO1 or R-spondin-1 activates the canonical Wnt pathway through ligand binding to the LGR4-6 receptor, forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction upregulates target gene expression. RSPO1/R-spondin-1 Protein, Human (HEK293, His) is the recombinant human-derived RSPO1/R-spondin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of RSPO1/R-spondin-1 Protein, Human (HEK293, His) is 243 a.a., with molecular weight of ~35 kDa.
  • HY-P72784A
    RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, His)
    1 Publications Verification

    R-spondin-1; Roof plate-specific spondin-1; RSPO1

    		 Human HEK293
    RSPO1, or R-spondin-1, activates the canonical Wnt pathway by ligand binding to LGR4-6 receptors, forming a complex with phosphorylated LRP6 and frizzled receptors. This interaction upregulates target gene expression. RSPO1 inhibits ZNRF3, a Wnt regulator, modulating both canonical and non-canonical Wnt pathways. It acts as a ligand for FZD8 and LRP6, negatively regulating the TGF-beta pathway and influencing ovary determination. RSPO1 counteracts DKK1/KREM1-mediated LRP6 internalization and interacts with FZD8, LRP6, RNF43, LGR5, and heparin, contributing to its diverse role in Wnt pathway regulation. RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, His) is the recombinant human-derived RSPO1/R-spondin-1 protein, expressed by HEK293, with C-8*His labeled tag. The total length of RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, His) is 126 a.a., with molecular weight of 17-25 kDa.
  • HY-P78344
    RSPO1/R-spondin-1 Protein, Mouse (HEK293, His)

    R-spondin-1; RSPO1; CRISTIN3; FLJ40906; RP11-566C13.1; RSPO

    		 Mouse HEK293
    RSPO1 activates the canonical Wnt signaling pathway by binding to LGR4-6 receptors, triggering increased expression of target genes. It inhibits ZNRF3, regulating the Wnt signaling pathway, and negatively regulates the TGF-beta pathway. RSPO1 also plays a role in ovary determination and interacts with various proteins including FZD8, LRP6, and WNT1. It forms complexes with RNF43, LGR5, and LGR6, and promotes membrane clearance of ZNRF3. RSPO1 binds heparin and interacts with LGR4, LGR5, and LGR6. RSPO1/R-spondin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived RSPO1/R-spondin-1 protein, expressed by HEK293, with C-His labeled tag. The total length of RSPO1/R-spondin-1 Protein, Mouse (HEK293, His) is 245 a.a., with molecular weight of 40-50 kDa.
  • HY-P7114
    RSPO1/R-spondin-1 Protein, Human (CHO, His)
    Maximum Cited Publications
    8 Publications Verification

    rHuR-spondin-1/RSPO1; Roof plate-specific spondin-1

    		 Human CHO
    RSPO1/R-spondin-1 Protein, Human is a secreted protein that activates Wnt signaling.
  • HY-P700443
    RSPO1/R-spondin-1 Protein, Human (HEK293, His-Avi)

    rHuR-spondin-1/RSPO1; Roof plate-specific spondin-1

    		 Human HEK293
    RSPO1, or R-spondin-1, activates the canonical Wnt pathway by ligand binding to LGR4-6 receptors, forming a complex with phosphorylated LRP6 and frizzled receptors. This interaction upregulates target gene expression. RSPO1 inhibits ZNRF3, a Wnt regulator, modulating both canonical and non-canonical Wnt pathways. It acts as a ligand for FZD8 and LRP6, negatively regulating the TGF-beta pathway and influencing ovary determination. RSPO1 counteracts DKK1/KREM1-mediated LRP6 internalization and interacts with FZD8, LRP6, RNF43, LGR5, and heparin, contributing to its diverse role in Wnt pathway regulation. RSPO1/R-spondin-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived RSPO1/R-spondin-1 protein, expressed by HEK293, with C-Avi, C-10*His labeled tag. The total length of RSPO1/R-spondin-1 Protein, Human (HEK293, His-Avi) is 233 a.a., with molecular weight of 30.2 kDa.
  • HY-P700255
    RSPO1/R-spondin-1 Protein, Mouse (189aa, His)

    		Mouse E. coli
    RSPO1 activates the canonical Wnt signaling pathway by binding to LGR4-6 receptors, triggering increased expression of target genes. It inhibits ZNRF3, regulating the Wnt signaling pathway, and negatively regulates the TGF-beta pathway. RSPO1 also plays a role in ovary determination and interacts with various proteins including FZD8, LRP6, and WNT1. It forms complexes with RNF43, LGR5, and LGR6, and promotes membrane clearance of ZNRF3. RSPO1 binds heparin and interacts with LGR4, LGR5, and LGR6. RSPO1/R-spondin-1 Protein, Mouse (189aa, His) is the recombinant mouse-derived RSPO1/R-spondin-1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of RSPO1/R-spondin-1 Protein, Mouse (189aa, His) is 189 a.a., with molecular weight of ~23 kDa.

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