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Results for "

SGD

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Fluorescent Dyes

1

Biochemical Assay Reagents

2

Inhibitory Antibodies

1

Oligonucleotides

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15162
    Monomethyl auristatin E
    50+ Cited Publications

    MMAE; SGD-1010

    		 Microtubule/Tubulin ADC Payload Apoptosis Cancer
    Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
    Monomethyl auristatin E
  • HY-101127
    SGD-1882

    PBD dimer

    		 ADC Payload Cancer
    SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
    SGD-1882
  • HY-101162
    SGD-1910

    		Drug-Linker Conjugates for ADC Cancer
    SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala .
    SGD-1910
  • HY-15162R
    Monomethyl auristatin E (Standard)

    MMAE (Standard); SGD-1010 (Standard); Vedotin (Standard)

    		 Reference Standards Microtubule/Tubulin Apoptosis Cancer
    Monomethyl auristatin E (MMAE) (Standard) is the analytical standard of Monomethyl auristatin E (HY-15162). This product is intended for research and analytical applications. Monomethyl auristatin E is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) against several different cancer types .
    Monomethyl auristatin E (Standard)
  • HY-15162G
    Monomethyl auristatin E

    MMAE; SGD-1010; Vedotin

    		 Microtubule/Tubulin Apoptosis ADC Payload Cancer
    Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .
    Monomethyl auristatin E
  • HY-P99238
    Rolinsatamab

    		ADC Antibody Inflammation/Immunology Cancer
    Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
    Rolinsatamab
  • HY-126678
    Dimethyl-SGD-1882

    Dimethyl-PBD dimer

    		 ADC Payload Cancer
    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .
    Dimethyl-SGD-1882
  • HY-162941
    SGD-9501-TFA

    		ADC Linker Cancer
    GD-9501-TFA is an auristatin S-based ADC linker with effective off-target toxicity characteristics, which can be used for the preparation of antibody-drug conjugates (ADCs) .
    SGD-9501-TFA
  • HY-P99881
    Rolinsatamab talirine

    ABBV 176

    		 Antibody-Drug Conjugates (ADCs) Cancer
    Rolinsatamab talirine (ABBV 176) is a prolactin receptor (PRLR)-targeting antibody-drug conjugate (ADC), compoused of Rolinsatamab (HY-P99238) and SGD-1882 (HY-101127). Rolinsatamab talirine binds to PRLR to deliver a cytotoxin to tumor cells. Rolinsatamab talirine induces DNA damage, and exhibits cytotoxicity against multiple breast tumor models, including triple negative and low PRLR-expressing models. Rolinsatamab talirine demonstrates enhanced anti-tumor activity in several breast cancer models. Rolinsatamab talirine can be used for the research of breast cancer, hepatocellular carcinoma, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, adrenocortical carcinoma, and solid tumors .
    Rolinsatamab talirine
  • HY-15387
    Beclobrate

    SGD 24774

    		 Drug Derivative Cardiovascular Disease
    Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents .
    Beclobrate
  • HY-136880
    Flufylline

    SGD 195/78

    		 5-HT Receptor Cardiovascular Disease
    Flufylline shows antihypertensive properties in spontaneously hypertensive rats and display antagonism towards 5-HT receptors in various animal models. Flufylline can be used for cardiovascular disease research .
    Flufylline
  • HY-RS12792
    SGCD Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SGCD Human Pre-designed siRNA Set A contains three designed siRNAs for SGCD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SGCD Human Pre-designed siRNA Set A
    SGCD Human Pre-designed siRNA Set A
  • HY-148760
    SGD-1882-Dap-Val

    		Drug Intermediate ADC Payload Others
    SGD-1882-Dap-Val is an intermediate compound. SGD-1882-Dap-Val can be used in the synthesis of antibody-drug conjugates (ADCs) .
    SGD-1882-Dap-Val

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