1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. Dimethyl-SGD-1882

Dimethyl-SGD-1882 (Synonyms: Dimethyl-PBD dimer)

Cat. No.: HY-126678
Handling Instructions

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication.

For research use only. We do not sell to patients.

Dimethyl-SGD-1882 Chemical Structure

Dimethyl-SGD-1882 Chemical Structure

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Description

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

IC50 & Target[1]

Pyrrolobenzodiazepines

 

In Vitro

The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].

Molecular Weight

753.84

Formula

C₄₄H₄₃N₅O₇

SMILES

C[[email protected]@]12N(C(C3=CC(OC)=C(OCCCOC4=C(C=C5C(N=C[[email protected]]6(C)N(C=C(C7=CC=C(OC)C=C7)C6)C5=O)=C4)OC)C=C3N=C2)=O)C=C(C8=CC=C(N)C=C8)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Dimethyl-SGD-1882Dimethyl-PBD dimerADC CytotoxinInhibitorinhibitorinhibit

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Dimethyl-SGD-1882
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