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Pathways Recommended:	PROTAC

Results for "

TEAD1/IAP PROTAC degrader

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IAP (4) Ligands for Target Protein for PROTAC (3) PROTAC Linkers (1) SNIPERs (4) E3 Ligase Ligand-Linker Conjugates (2) Ligands for E3 Ligase (2) PROTACs (4) Target Protein Ligand-Linker Conjugates (1) YAP (9)
By Research Areas:	Cancer (10)
Click Chemistry:	PROTAC Synthesis (3)

Inhibitors & Agonists

Click Chemistry

Targets Recommended: IAP PROTAC-Linker Conjugates for PAC PROTAC Linkers SNIPERs Ligands for Target Protein for PROTAC

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-181590

PROTAC TEAD1/IAP degrader-3	PROTACs SNIPERs YAP IAP	Cancer
PROTAC TEAD1/IAP degrader-3 is a *TEAD1/IAP* *PROTAC* degrader. PROTAC TEAD1/IAP degrader-3 recruits the cIAP1 and XIAP E3 ligases to form a ternary complex, drives proteasomal degradation of *TEAD1, and triggers autoubiquitination and proteasomal degradation* of cIAP1. PROTAC TEAD1/IAP degrader-3 inhibits cell proliferation. PROTAC TEAD1/IAP degrader-3 regulates Hippo pathway activity by downregulating CTGF gene expression in a TEAD-dependent manner. PROTAC TEAD1/IAP degrader-3 is applicable to the research of mesothelioma .

HY-181534

PROTAC TEAD1/IAP degrader-1	PROTACs YAP IAP SNIPERs	Cancer
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 *PROTAC* degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181537

PROTAC TEAD1/IAP degrader-2	PROTACs SNIPERs YAP IAP	Cancer
PROTAC TEAD1/IAP degrader-2 is an *IAP*-harnessing **TEAD1 PROTAC** degrader, with a DC₅₀ of 170 nM against TEAD1 in NCI-H2052 cells. PROTAC TEAD1/IAP degrader-2 exhibits moderate antiproliferative activity in Hippo pathway-dependent mesothelioma cells. PROTAC TEAD1/IAP degrader-2 inhibits the expression of CTGF, but with a weaker effect than the TEAD inhibitor VT-107 (HY-134957). PROTAC TEAD1/IAP degrader-2 can be used in mesothelioma-related research .

HY-181536

TEAD ligand 2	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

HY-181593

IAP ligand-Linker Conjugate 2	E3 Ligase Ligand-Linker Conjugates	Cancer
IAP ligand-Linker Conjugate 2 is a synthetic target E3 ligase ligand-linker conjugate that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-3 (HY-181590). PROTAC TEAD degrader-2 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

HY-181530

IAP ligand 6	YAP Ligands for E3 Ligase	Cancer
IAP ligand 6 (A250) is an *IAP* ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534) .

HY-181535

IAP ligand-Linker Conjugate 1	E3 Ligase Ligand-Linker Conjugates IAP	Others
IAP ligand-Linker Conjugate 1 is a ligand-linker conjugate targeting *IAP, which can be used in the synthesis of PROTAC* TEAD1/IAP degrader-1 (HY-181534) .

HY-W803227

1-(2-Chloro-acetyl)-piperazine	PROTAC Linkers	Cancer
1-(2-Chloro-acetyl)-piperazine is a PROTAC linker. 1-(2-Chloro-acetyl)-piperazine can be used to synthesize PROTAC TEAD1/IAP degrader-2 (HY-181537) .

HY-181591

IAP ligand 10	Ligands for E3 Ligase	Cancer
IAP ligand 10 is an E3 ligase ligand (E3 ligase ligand). E3 ligase Ligand 58 can be used for the synthesis of PROTAC TEAD1/IAP degrader-3 (HY-181590) .

HY-181539

TEAD ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates YAP	Others
TEAD ligand-Linker Conjugate 2 (compound S24) is a conjugate of *TEAD*‑targeted ligand and linker, which can be used for the synthesis of PROTAC TEAD1/IAP degrader-2 (HY-181537) .

HY-181538

TEAD ligand 3	Ligands for Target Protein for PROTAC YAP	Others
TEAD ligand 3 (compound S20) is a *TEAD* ligand. As a target protein ligand, TEAD ligand 3 can be used in the synthesis of PROTAC TEAD1/IAP degrader-2 (HY-181537) .

HY-181592

TEAD ligand 4	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 4 is a *TEAD* *PROTAC* ligand. TEAD ligand 4 can be conjugated with E3 ligase Ligand (HY-181591) and linker to synthesize PROTAC TEAD1/IAP degrader (HY-181590) .

HY-181594

PROTAC TEAD/IAP degrader-1	PROTACs SNIPERs YAP	Cancer
PROTAC TEAD/IAP degrader-1 is a *TEAD/IAP* *PROTAC* degrader. PROTAC TEAD/IAP degrader-1 is also a specific and Nongenetic inhibitor of apoptosis protein (IAP)-dependent protein eraser (SNIPERs). PROTAC TEAD/IAP degrader-1 recruits cIAP1 to form ternary complexes, induces ubiquitination, proteasomal *TEAD1, TEAD4* degradation. PROTAC TEAD/IAP degrader-1 inhibits TEAD transcriptional activity, reduces CTGF expression, and reduces cell proliferation. PROTAC TEAD/IAP degrader-1 can be used for the research of mesothelioma .

Cat. No.	상품명		Classification

HY-181534

PROTAC TEAD1/IAP degrader-1		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 *PROTAC* degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181536

TEAD ligand 2		PROTAC Synthesis
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

HY-181530

IAP ligand 6		PROTAC Synthesis
IAP ligand 6 (A250) is an *IAP* ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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