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TLS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (2) Small Interfering RNA (siRNA) (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (3) Metabolic Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126214

JH-RE-06 4 Publications Verification	DNA/RNA Synthesis	Cancer
JH-RE-06, a potent REV1-REV7 interface inhibitor (IC₅₀=0.78 μM; K_d=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

HY-108844

Rasburicase	Xanthine Oxidase	Metabolic Disease Cancer
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout .

HY-126214S

JH-RE-06-d6	DNA/RNA Synthesis	Cancer
JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC₅₀=0.78 μM; K_i=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

HY-RS05149

FUS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FUS Human Pre-designed siRNA Set A contains three designed siRNAs for FUS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FUS Human Pre-designed siRNA Set A FUS Human Pre-designed siRNA Set A

HY-RS17359

Fus Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fus Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fus gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fus Mouse Pre-designed siRNA Set A Fus Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108844

Rasburicase	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Xanthine Oxidase
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout .

Species:	Human (2)
Tag:	His (2) Myc (1) MBP (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704622

	FUS Protein, Human (MBP-His) RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein; TLS	Human	E. coli
	FUS Protein, Human (MBP-His) is the recombinant human-derived FUS protein, expressed by E. coli, with N-His & N-MBP tag.

HY-P702630

	FUS Protein, Human (His, Myc) RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein; TLS	Human	E. coli
	FUS Protein, Human (His, Myc) is the recombinant human-derived FUS, expressed by E. coli , with N-10*His, C-Myc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-126214S

JH-RE-06-d6
JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC₅₀=0.78 μM; K_i=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (1) WB (2) FC (1) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83452

	TLS/FUS Antibody (YA3197) FUS; FUS-CHOP; TLS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMP75; Translocated in liposarcoma protein	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	TLS/FUS Antibody (YA3197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TLS/FUS.

HY-P86540

	TLS/FUS Antibody (YA6232)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TLS/FUS Antibody (YA6232) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TLS/FUS.

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Cat. No.	Product Name		Classification

HY-RS05149

FUS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FUS Human Pre-designed siRNA Set A contains three designed siRNAs for FUS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17359

Fus Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Fus Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fus gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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