1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. JH-RE-06

JH-RE-06 

Cat. No.: HY-126214 Purity: >98.0%
Handling Instructions

JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 enhances Cisplatin-induced cytotoxicity and improves chemotherapy.

For research use only. We do not sell to patients.

JH-RE-06 Chemical Structure

JH-RE-06 Chemical Structure

CAS No. : 1361227-90-8

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 enhances Cisplatin-induced cytotoxicity and improves chemotherapy[1][2].

IC50 & Target

IC50: 0.78 μM (REV1-REV7)[1]
Kd: 0.42 μM (REV1-REV7)[1]

In Vitro

JH-RE-06 unexpectedly induces dimerization of the REV1 CTD at its REV7-binding surface and blocks the REV1-REV7 interaction[1].

In Vivo

JH-RE-06 inhibits mutagenic TLS and enhances cisplatin-induced toxicity in cultured human and mouse cell lines[1].
Co-administration of JH-RE-06 with cisplatin suppresses the growth of xenograft human melanomas in mice[1].

Molecular Weight

468.72

Formula

C₂₀H₁₆Cl₃N₃O₄

CAS No.

1361227-90-8

SMILES

O=C1C(C(CC(C)C)=O)=C(NC2=CC=C(Cl)C=C2Cl)NC3=C1C([N+]([O-])=O)=CC=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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JH-RE-06
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HY-126214
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