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Isoforms Recommended:	TRPML

Results for "

TRPML1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Parasite (1) TRP Channel (8)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Metabolic Disease (1) Neurological Disease (4)

8

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134818

ML-SI1

4 Publications Verification

TRP Channel Neurological Disease

ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC₅₀ value of 15 μM for TRPML1 ^[1].

ML-SA5	TRP Channel	Cancer
ML-SA5 is a potent *TRPML1* cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC₅₀ of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth ^[1].

(rel)-ML-SI3 trans-ML-SI3	TRP Channel Autophagy	Cancer
(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a *TRPML* Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC₅₀s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy ^[1] .

HY-110238

MK6-83

TRP Channel Metabolic Disease

MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study ^[1].
HY-162095

TRPML1 agonist 1

TRP Channel Neurological Disease

TRPML1 agonist 1 (compound 18) is a potent TRPML1 agonist with an EC₅₀ value of 0.27 µM ^[1].

ML-SI3 ML-SI3 (cis/trans mix)	Parasite TRP Channel	Cardiovascular Disease Neurological Disease
ML-SI3 is a mixture of cis/trans ML-SI3. ML-SI3 is a *TRPML* channel modulator. ML-SI3 blocks *TRPML1* and *TRPML2* with IC₅₀s of 4.7 µM and 1.7 µM, respectively. ML-SI3 is also able to activate *TRPML2* and *TRPML3* with EC₅₀s of 3.3-9.4 μM and 29 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy.

(1S,2S)-ML-SI3 (+)-trans-ML-SI3	TRP Channel	Cancer
(1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a *TRPML* inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC₅₀=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC₅₀=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC₅₀=5.9 μM), but an activator on TRPML 2 and 3 (EC₅₀=2.7 μM/10.8 μM) ^[1].

(1R,2R)-ML-SI3 (-)-trans-ML-SI3	TRP Channel	Neurological Disease
(1R,2R)-ML-SI3 is a potent inhibitor of both *TRPML1* and *TRPML2* (IC₅₀ values of 1.6 and 2.3 μM) and a weak inhibitor (IC₅₀ 12.5 μM) of TRPML3 ^[1].

Species:	Human (2)
Tag:	His (1) Strep (1) Flag (1)
Source:	HEK293 (1) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

	MCOLN1 Protein, Human (Cell-Free, His) Mucolipin-1; MG-2; Mucolipidin; Transient receptor potential channel mucolipin 1; TRPML1	Human	E. coli Cell-free
	The TRPML1 protein is a nonselective cation channel that regulates membrane trafficking and metal homeostasis. It promotes the release of Ca(2+) in late endosomes and lysosomes, affecting organelle fusion, exocytosis and autophagy. MCOLN1 Protein, Human (Cell-Free, His) is the recombinant human-derived MCOLN1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of MCOLN1 Protein, Human (Cell-Free, His) is 580 a.a., with molecular weight of 66.5 kDa.

	TRPML1 Protein, Human (HEK293, Strep, FLAG) MCOLN1 (ML4, TRPML1); Mucolipin-1; MG-2; Mucolipidin; Transient receptor potential channel mucolipin 1 (TRPML1)	Human	HEK293
	The TRPML1 protein is a nonselective cation channel that regulates membrane trafficking and metal homeostasis. It promotes the release of Ca(2+) in late endosomes and lysosomes, affecting organelle fusion, exocytosis and autophagy. TRPML1 Protein, Human (HEK293, Strep, FLAG) is the recombinant human-derived TRPML1 protein, expressed by HEK293 , with N-Strep, C-Flag labeled tag. The total length of TRPML1 Protein, Human (HEK293, Strep, FLAG) is 580 a.a., .

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