1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. MK6-83

MK6-83 

Cat. No.: HY-110238
Handling Instructions

MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study.

For research use only. We do not sell to patients.

MK6-83 Chemical Structure

MK6-83 Chemical Structure

CAS No. : 1062271-24-2

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Description

MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].

In Vitro

MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1].
MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1].

Cell Viability Assay[1].

Cell Line: Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation[1].
Concentration: 0-10 μM.
Incubation Time: 24 h.
Result: Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells.
Had no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.
Molecular Weight

336.47

Formula

C₁₆H₂₀N₂O₂S₂

CAS No.

1062271-24-2

SMILES

O=S(C1=CC=C(C)S1)(NC2=CC=CC=C2N3CCCCC3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MK6-83TRP ChannelTransient receptor potential channelsMucolipidosislysosomefibroblastcellInhibitorinhibitorinhibit

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