2. Membrane Transporter/Ion Channel Autophagy Neuronal Signaling
  3. Autophagy TRP Channel
  4. (rel)-ML-SI3

(rel)-ML-SI3  (Synonyms: trans-ML-SI3)

Cat. No.: HY-139426A Purity: 99.81%
COA Handling Instructions

Molarity Calculator

(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.

For research use only. We do not sell to patients.

(rel)-ML-SI3 Chemical Structure

(rel)-ML-SI3 Chemical Structure

CAS No. : 2108567-79-7

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Based on 1 publication(s) in Google Scholar

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Description

(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][2].

IC50 & Target

TRPML1

3.1 μM (IC50)

TRPML2

3.3 μM (EC50)

TRPML3

28.5 μM (IC50)

Molecular Weight

429.58

Formula

C23H31N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3279 mL 11.6393 mL 23.2786 mL
5 mM 0.4656 mL 2.3279 mL 4.6557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

COA (253 KB) HNMR (288 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3279 mL 11.6393 mL 23.2786 mL 58.1964 mL
5 mM 0.4656 mL 2.3279 mL 4.6557 mL 11.6393 mL
10 mM 0.2328 mL 1.1639 mL 2.3279 mL 5.8196 mL
15 mM 0.1552 mL 0.7760 mL 1.5519 mL 3.8798 mL
20 mM 0.1164 mL 0.5820 mL 1.1639 mL 2.9098 mL
25 mM 0.0931 mL 0.4656 mL 0.9311 mL 2.3279 mL
30 mM 0.0776 mL 0.3880 mL 0.7760 mL 1.9399 mL
40 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4549 mL
50 mM 0.0466 mL 0.2328 mL 0.4656 mL 1.1639 mL
60 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL
80 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.5820 mL
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(rel)-ML-SI3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rel)-ML-SI32108567-79-7trans-ML-SI3AutophagyTRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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