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Results for "

VISTA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Autophagy (1) IFNAR (1) PD-1/PD-L1 (3)
By Research Areas:	Cancer (4) Inflammation/Immunology (5)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13570C

Betamethasone disodium phosphate Betamethasone 21-phosphate disodium salt; VISTA-Methasone	Others	Others
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids .

HY-147179

INX-SM-56	ADC Cytotoxin	Inflammation/Immunology
INX-SM-56 is a cytotoxin that can be used for the synthesis of anti-VISTA antibody agent conjugate. VISTA: V-region Immunoglobulin-containing Suppressor of T cell Activation .

HY-157937

VISTA-IN-3	IFNAR	Cancer
VISTA-IN-3 (Compound A4) is a potent *VISTA* small molecule inhibitor with a K_D value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody .

HY-155971

VISTA-IN-2	Autophagy	Inflammation/Immunology Cancer
VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA). VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model .

HY-13570CR

Betamethasone disodium phosphate (Standard) Betamethasone 21-phosphate disodium salt (Standard); VISTA-Methasone (Standard)	Others	Others
Betamethasone disodium phosphate (Standard) is the analytical standard of Betamethasone disodium phosphate. This product is intended for research and analytical applications. Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids .

HY-147311

NSC622608

PD-1/PD-L1 Inflammation/Immunology

NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC₅₀ value of 4.8 μM .

NSC622608	PD-1/PD-L1	Inflammation/Immunology
NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC₅₀ value of 4.8 μM .

HY-101093

CA-170 1 Publications Verification	PD-1/PD-L1	Inflammation/Immunology Cancer
CA-170 is an orally delivered dual inhibitor of *VISTA* and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .

HY-147119

INX-SM-6	ADC Cytotoxin	Inflammation/Immunology
INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS .

HY-P99040

Onvatilimab JNJ-61610588	PD-1/PD-L1	Cancer
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab has an anti-tumor activity .

Cat. No.	Product Name	Target	Research Area

HY-P99040

Onvatilimab JNJ-61610588	PD-1/PD-L1	Cancer
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab has an anti-tumor activity .

HY-P990145

Anti-Mouse VISTA Antibody (13F3)

Inhibitory Antibodies Others

Anti-Mouse VISTA Antibody (13F3) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse VISTA.

*Anti-Mouse VISTA* Antibody (13F3)**	Inhibitory Antibodies	Others
Anti-Mouse VISTA Antibody (13F3) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse VISTA.

Recombinant Proteins Recommended:

VISTA

Species:	Human (3) Rhesus Macaque (2) Mouse (2) Rat (1) Cynomolgus (2)
Tag:	His (5) Avi (1) Fc (5)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P70983

	VISTA/B7-H5 Protein, Human (HEK293, His) VISTA; B7-H5; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (HEK293, His) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VISTA/B7-H5 Protein, Human (HEK293, His) is 162 a.a., with molecular weight of 30-50 kDa.

HY-P72428

	VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) V-type immunoglobulin domain-containing suppressor of T-cell activation; Vsir; Dies1; PD-1H; VISTA	Mouse	HEK293
	VISTA/B7-H5 Protein is a type I transmembrane protein expressed primarily in white blood cells that inhibits T cell function. VISTA/B7-H5 Protein promotes embryonic stem cell differentiation by inhibiting BMP4 signaling and stimulates MMP14 mediated MMP2 activation. VISTA/B7-H5 Protein is highly expressed in tumors. VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) is the recombinant mouse-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) is 159 a.a., with molecular weight of 30-40 kDa.

HY-P73546

	VISTA/B7-H5 Protein, Rat (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Rat	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Rat (HEK293, Fc) is the recombinant rat-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Rat (HEK293, Fc) is 159 a.a., with molecular weight of ~44.7 kDa.

HY-P73544

	VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Rhesus Macaque	HEK293
	VISTA/B7-H5 protein is an immune regulatory receptor that can inhibit the activation of T cells and regulate immune responses as a ligand and receptor. VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-His labeled tag. The total length of VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) is 162 a.a., with molecular weight of ~19.6 kDa.

HY-P73547

	VISTA/B7-H5 Protein, Mouse (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Mouse	HEK293
	VISTA/B7-H5 Protein is a type I transmembrane protein expressed primarily in white blood cells that inhibits T cell function. VISTA/B7-H5 Protein promotes embryonic stem cell differentiation by inhibiting BMP4 signaling and stimulates MMP14 mediated MMP2 activation. VISTA/B7-H5 Protein is highly expressed in tumors. VISTA/B7-H5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Mouse (HEK293, Fc) is 191 a.a., with molecular weight of ~44.5 kDa.

HY-P73545

	VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Rhesus Macaque	HEK293
	VISTA/B7-H5 protein is an immune regulatory receptor that can inhibit the activation of T cells and regulate immune responses as a ligand and receptor. VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) is 194 a.a., with molecular weight of ~44.9 kDa.

HY-P77879

	VISTA/B7-H5 Protein, Human (HEK293, Fc) B7H5; B7-H5; VISTA; VSIR ; PD1H; PD-1H; 4632428N05Rik; C10orf54; Dies1; Gi24; PP2135; SISP1	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (HEK293, Fc) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Human (HEK293, Fc) is 162 a.a., with molecular weight of 70-80 kDa.

HY-P70962

	VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Cynomolgus	HEK293
	VISTA/B7-H5 Protein is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells. VISTA inhibits T cell activation, proliferation, and cytokine production. VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) is 162 a.a., with molecular weight of 30-50 kDa.

HY-P73482

	VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Cynomolgus	HEK293
	VISTA/B7-H5 Protein is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells. VISTA inhibits T cell activation, proliferation, and cytokine production. VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) is 162 a.a., with molecular weight of ~44.9 kDa.

HY-P78936

	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) is 162 a.a., with molecular weight of 36-47 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81531

VISTA Antibody (YA1276) VSIR; PP2135, UNQ730/PRO1412; C10orf54, SISP1; VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; Stress-induced secreted protein-1; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor	IHC-P	Human

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