2. Immunology/Inflammation
  3. VISTA
  4. Anti-Mouse VISTA Antibody (13F3)

Anti-Mouse VISTA Antibody (13F3) 

Cat. No.: HY-P990145 Purity: ≥95.0%
COA
SDS
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Anti-Mouse VISTA Antibody (13F3) is an anti-mouse VISTA IgG monoclonal antibody. Anti-Mouse VISTA Antibody (13F3) can reverse the immunosuppressive effect of VISTA by blocking its binding to ligands such as VSIG3. Anti-Mouse VISTA Antibody (13F3) exacerbates pulmonary fibrosis (PF) by promoting Th17 cell differentiation. Anti-Mouse VISTA Antibody (13F3) can be used for research on cancer such as breast cancer and PF.

For research use only. We do not sell to patients.

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Description

Anti-Mouse VISTA Antibody (13F3) is an anti-mouse VISTA IgG monoclonal antibody. Anti-Mouse VISTA Antibody (13F3) can reverse the immunosuppressive effect of VISTA by blocking its binding to ligands such as VSIG3. Anti-Mouse VISTA Antibody (13F3) exacerbates pulmonary fibrosis (PF) by promoting Th17 cell differentiation. Anti-Mouse VISTA Antibody (13F3) can be used for research on cancer such as breast cancer and PF[1][2].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

VISTA
In Vivo

Anti-Mouse VISTA Antibody (13F3) (50 μg, intratumoral injection, on day 7, 9, 12, 14 and 16) significantly inhibits tumor growth in Balb/c mice bearing 4T1 tumors[1].
Anti-Mouse VISTA Antibody (13F3) (i.p., once every 3 days, from day 7 to day 21) aggravates pulmonary fibrosis in C57BL/6 mice with a Bleomycin hydrochloride (BLM) (HY-17565A) induced pulmonary fibrosis (PF) model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2×104 4T1 cells injected Balb/c mice[1]
Dosage: 50 μg
Administration: intratumoral injection, on day 7, 9, 12, 14 and 16
Result: Significantly inhibited tumor volume (inhibition rate of 53%).
Gene ID

74048  [NCBI]

Accession
Application

in vivo blocking of VISTA signaling; in vitro blocking of VISTA signaling; Flow cytometry
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse VISTA Antibody (13F3)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His, HY-P72428) can bind Anti-Mouse VISTA Antibody (13F3). The EC50 for this effect is 71.89 ng/mL.
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Anti-Mouse VISTA Antibody (13F3) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse VISTA Antibody (13F3)VISTAV-domain Ig suppressor of T cell activation (VISTA)PF4T1Inhibitorinhibitorinhibit

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