Vsir - V-set immunoregulatory receptor Gene

Also Known as Dies1; PD-1H; VISTA; 4632428N05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74048

Summary

Predicted to enable endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of T cell cytokine production; and positive regulation of BMP signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including heart; immune system; lung; male reproductive gland or organ; and small intestine lamina propria. Orthologous to human VSIR (V-set immunoregulatory receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vsir Products (2)

mRNA	Protein	Name
NM_001159572.1	NP_001153044.1	V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 2 precursor
NM_028732.4	NP_083008.1	V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20042595	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	20042595	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	22751012	MGI
acts upstream of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20042595	MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	21383057	MGI
acts upstream of or within negative regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	21383057	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	20042595	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20042595	MGI
acts upstream of or within positive regulation of stem cell differentiation	IGI IGI: Inferred from genetic interaction	22751012	MGI
acts upstream of stem cell differentiation	IGI IGI: Inferred from genetic interaction	22751012	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20042595	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	20042595	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20042595	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
V-type immunoglobulin domain-containing suppressor of T-cell activation	V-set domain-containing immunoregulatory receptor differentiation of ESCs 1 platelet receptor Gi24

Recombinant Vsir Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72428	VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His)	Q9D659 (F33-A191)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73547	VISTA/B7-H5 Protein, Mouse (HEK293, Fc)	Q9D659 (F33-A194)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15711	VSIR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18981	Vsir Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25470	Vsir Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991447	Anti-VSIR/VISTA Antibody (SG7)	Inhibitor	98.07%	Unkown
HY-P991165	Trovostobart		99.17%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vsir	NCBI	NCBI:64115