VSIR - V-set immunoregulatory receptor Gene

Homo sapiens

Also known as B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha

Gene ID: 64115 | Gene type: protein coding

About VSIR

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,747,556-71,773,520 (from NCBI)

This gene has 3 transcripts (splice variants), 482 orthologues and 14 paralogues. Broad expression in spleen (RPKM 39.2), bone marrow (RPKM 38.8) and 23 other tissues.

Summary

Enables endopeptidase activator activity; Enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

VSIR Products(1)

mRNA	Protein	Name
NM_022153.2	NP_071436.1	V-type immunoglobulin domain-containing suppressor of T-cell activation precursor

VSIR Protein Structure

V-set

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

V-type immunoglobulin domain-containing suppressor of T-cell activation

Death Domain1alpha

Recombinant VSIR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7591	Recombinant Human VISTA/B7-H5/PD-1H Protein (CHO-expressed)	Q9H7M9	/
HY-P70983	VISTA/B7-H5 Protein, Human (HEK293, His)	AAH20568.1 (F33-A194)	≥95%
HY-P77879	VISTA/B7-H5 Protein, Human (HEK293, Fc)	Q9H7M9 (F33-A194)	≥95%
HY-P78929	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9H7M9 (F33-A194)	≥95%
HY-P78936	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9H7M9 (F33-A194)	≥95%

Related Diseases

Diseases

Alias

Hard Palate Cancer

Malignant Neoplasm Of Hard Palate	Malignant Tumor Of Hard Palate
Malignant Tumour Of Hard Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15711	VSIR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VSIR	VGNC	VGNC:79834
Canis familiaris	VSIR	VGNC	VGNC:51998
Bos taurus	VSIR	VGNC	VGNC:50150
Rattus norvegicus	VSIR	RGD	RGD:1590938
Felis catus	VSIR	VGNC	VGNC:66980
Mus musculus	VSIR	MGD	MGI:1921298
Others	VSIR	NCBI