1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. NSC622608

NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM.

For research use only. We do not sell to patients.

NSC622608 Chemical Structure

NSC622608 Chemical Structure

CAS No. : 2593254-90-9

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5 mg USD 110 In-stock
10 mg USD 190 In-stock
25 mg USD 380 In-stock
50 mg USD 570 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM[1].

IC50 & Target

IC50: 4.8 μM (VISTA)[1]

In Vitro

NSC622608 disrupts VISTA-VSIG-3 interaction with an IC50 value of 9.7 ± 0.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

322.25

Formula

C9H12BrN3OS2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)C1=N/C(SS1)=N/CC2=CC=CO2.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (129.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 12.5 mg/mL (38.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1032 mL 15.5159 mL 31.0318 mL
5 mM 0.6206 mL 3.1032 mL 6.2064 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.1032 mL 15.5159 mL 31.0318 mL 77.5795 mL
5 mM 0.6206 mL 3.1032 mL 6.2064 mL 15.5159 mL
10 mM 0.3103 mL 1.5516 mL 3.1032 mL 7.7580 mL
15 mM 0.2069 mL 1.0344 mL 2.0688 mL 5.1720 mL
20 mM 0.1552 mL 0.7758 mL 1.5516 mL 3.8790 mL
25 mM 0.1241 mL 0.6206 mL 1.2413 mL 3.1032 mL
30 mM 0.1034 mL 0.5172 mL 1.0344 mL 2.5860 mL
DMSO 40 mM 0.0776 mL 0.3879 mL 0.7758 mL 1.9395 mL
50 mM 0.0621 mL 0.3103 mL 0.6206 mL 1.5516 mL
60 mM 0.0517 mL 0.2586 mL 0.5172 mL 1.2930 mL
80 mM 0.0388 mL 0.1939 mL 0.3879 mL 0.9697 mL
100 mM 0.0310 mL 0.1552 mL 0.3103 mL 0.7758 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NSC622608 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NSC622608
Cat. No.:
HY-147311
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