NSC622608
Based on 1 Customer Validation
NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM.
For research use only. We do not sell to patients.
- Purity: 98.68%
- CAS No.: 2593254-90-9
- Formula: C9H12BrN3OS2
- Molecular Weight:322.25
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 4.8 μM (VISTA)[1]
NSC622608 disrupts VISTA-VSIG-3 interaction with an IC50 value of 9.7 ± 0.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2593254-90-9
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Appearance Solid
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Molecular Weight 322.25
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Formula C9H12BrN3OS2
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Color White to off-white
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SMILES
CN(C)C1=N/C(SS1)=N/CC2=CC=CO2.Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 41.67 mg/mL (129.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 12.5 mg/mL (38.79 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.1032 mL | 15.5159 mL | 31.0318 mL | 77.5795 mL |
| 5 mM | 0.6206 mL | 3.1032 mL | 6.2064 mL | 15.5159 mL | |
| 10 mM | 0.3103 mL | 1.5516 mL | 3.1032 mL | 7.7580 mL | |
| 15 mM | 0.2069 mL | 1.0344 mL | 2.0688 mL | 5.1720 mL | |
| 20 mM | 0.1552 mL | 0.7758 mL | 1.5516 mL | 3.8790 mL | |
| 25 mM | 0.1241 mL | 0.6206 mL | 1.2413 mL | 3.1032 mL | |
| 30 mM | 0.1034 mL | 0.5172 mL | 1.0344 mL | 2.5860 mL | |
| DMSO | 40 mM | 0.0776 mL | 0.3879 mL | 0.7758 mL | 1.9395 mL |
| 50 mM | 0.0621 mL | 0.3103 mL | 0.6206 mL | 1.5516 mL | |
| 60 mM | 0.0517 mL | 0.2586 mL | 0.5172 mL | 1.2930 mL | |
| 80 mM | 0.0388 mL | 0.1939 mL | 0.3879 mL | 0.9697 mL | |
| 100 mM | 0.0310 mL | 0.1552 mL | 0.3103 mL | 0.7758 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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