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Results for "

gingerol

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

14

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14615
    [6]-Gingerol
    Maximum Cited Publications
    13 Publications Verification

    (S)-(+)-[6]gingerol

    		 AMPK Apoptosis Cancer
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
    [6]-Gingerol
  • HY-N0448
    10-Gingerol
    4 Publications Verification

    		 AMPK Reactive Oxygen Species (ROS) Akt PI3K Interleukin Related TNF Receptor Apoptosis Neurological Disease Inflammation/Immunology Cancer
    10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 μM against DPPH radical, an IC50 value of 1.68 μM against superoxide radical and an IC50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol can be used in research on various common cancers such as ovarian cancer and colon cancer, as well as colitis and neurodegenerative diseases .
    10-Gingerol
  • HY-N0447
    8-Gingerol
    5 Publications Verification

    		 TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP Infection Cardiovascular Disease Inflammation/Immunology Cancer
    8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
    8-Gingerol
  • HY-14615R
    [6]-Gingerol (Standard)
    1 Publications Verification

    (S)-(+)-[6]gingerol (Standard)

    		 Reference Standards AMPK Apoptosis Cancer
    [6]-Gingerol (Standard) is the analytical standard of [6]-Gingerol. This product is intended for research and analytical applications. [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
    [6]-Gingerol (Standard)
  • HY-133865
    Diacetoxy-6-gingerdiol
    1 Publications Verification

    		 Interleukin Related Metabolic Disease Inflammation/Immunology
    Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .
    Diacetoxy-6-gingerdiol
  • HY-N0448R
    10-Gingerol (Standard)

    		Reference Standards Others Neurological Disease Inflammation/Immunology Cancer
    10-Gingerol (Standard) is the analytical standard of 10-Gingerol (HY-N0448). This product is intended for research and analytical applications. 10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 μM against DPPH radical, an IC50 value of 1.68 μM against superoxide radical and an IC50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis .
    10-Gingerol (Standard)
  • HY-N9947
    Methyl-6-gingerol

    		Bacterial Antibiotic Infection
    Methyl-6-gingerol is an antimicrobial agent derived from Aframomum melegueta that exhibits anti-mycobacterial activity by inhibiting the efflux of toxins within Mycobacterium species .
    Methyl-6-gingerol
  • HY-N16557
    (Rac)-8-Gingerol

    		Apoptosis EGFR STAT PERK Cancer
    (Rac)-8-Gingerol is a non-volatile component. (Rac)-8-Gingerol can be extracted from ginger. (Rac)-8-Gingerol enhances Apoptosis. (Rac)-8-Gingerol decreases the level of phosphorylated EGFR and, accordingly, the phosphorylation levels of its downstream effectors, STAT3 and ERK. (Rac)-8-Gingerol exhibits anticancer activity against colorectal cancer .
    (Rac)-8-Gingerol
  • HY-N0447R
    8-Gingerol (Standard)

    		Reference Standards TRP Channel Bacterial Infection Inflammation/Immunology Cancer
    8-Gingerol (Standard) is the analytical standard of 8-Gingerol. This product is intended for research and analytical applications. 8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 μM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro .
    8-Gingerol (Standard)
  • HY-N9947A
    (rac)-Methyl-6-gingerol

    		Antibiotic Bacterial Infection
    (rac)-Methyl-6-gingerol (Compound 14) is the racemate of Methyl-6-gingerol (HY-N9947). Methyl-6-gingerol is an antibiotic that can be isolated from Aframomum melegueta. Methyl-6-gingerol exhibits anti-mycobacterial activity by inhibiting the efflux of toxins within Mycobacterium species .
    (rac)-Methyl-6-gingerol
  • HY-N4303
    5-​Ethoxy-​10-​Gingerol

    		Drug Derivative Others
    5-​Ethoxy-​10-​Gingerol is a derivate of gingerol.
    5-​Ethoxy-​10-​Gingerol
  • HY-N15732
    Methyl-8-gingerol

    		Others Others
    Methyl-8-gingerol is a compound that can be isolated from ginger .
    Methyl-8-gingerol
  • HY-N15734
    6-Dehydro-10-gingerol

    		Parasite Infection
    6-Dehydro-10-gingerol is an antiparasitic compound that can be isolated from ginger roots .
    6-Dehydro-10-gingerol
  • HY-100187
    (Rac)-[6]-Gingerol

    (±)-[6]-gingerol

    		 Drug Isomer Cancer
    (Rac)-[6]-Gingerol is a natural product. (Rac)-[6]-Gingerol can be isolated from rhizomes of Z. officinale. (Rac)-[6]-Gingerol shows moderate anticancer activity against lung cancer, ovarian cancer, melanoma, and colon cancer .
    (Rac)-[6]-Gingerol
  • HY-N16862
    4-Gingerol

    		Drug Derivative Others
    4-Gingerol is a natural phenolic compound.
    4-Gingerol
  • HY-N15733
    5-Methoxy-[8]-gingerol

    		Others Others
    5-Methoxy-[8]-gingerol is a compound that can be isolated from ginger (Zingiber officinale) .
    5-Methoxy-[8]-gingerol

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