1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. 8-Gingerol

8-Gingerol 

Cat. No.: HY-N0447 Purity: 99.65%
Handling Instructions

8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro.

For research use only. We do not sell to patients.

8-Gingerol Chemical Structure

8-Gingerol Chemical Structure

CAS No. : 23513-08-8

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 202 In-stock
Estimated Time of Arrival: December 31
20 mg USD 343 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro[1][2].

Molecular Weight

322.44

Formula

C₁₉H₃₀O₄

CAS No.

23513-08-8

SMILES

CCCCCCC[[email protected]](O)CC(CCC1=CC=C(O)C(OC)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (310.14 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1014 mL 15.5068 mL 31.0135 mL
5 mM 0.6203 mL 3.1014 mL 6.2027 mL
10 mM 0.3101 mL 1.5507 mL 3.1014 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.65%

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Keywords:

8-GingerolTRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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8-Gingerol
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HY-N0447
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