23513-08-8
Chemical Structure
8-Gingerol
- CAS No.: 23513-08-8
- Formula:C19H30O4
- Molecular Weight:322.44
IUPAC Name: (S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one
InChIKey: BCIWKKMTBRYQJU-INIZCTEOSA-N
SMILES: CCCCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O
Biological Activity: 8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
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8-Gingerol | 99.72% | 8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases. | ||||||||||||||||||||
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8-Gingerol (Standard) | ≥98% | 8-Gingerol (Standard) is the analytical standard of 8-Gingerol. This product is intended for research and analytical applications. 8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 μM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro. | ||||||||||||||||||||
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Similarity Score 1.00
HY-N16557(Rac)-8-Gingerol -
Similarity Score 0.95
![(Rac)-[6]-Gingerol Chemical Structure](//file.medchemexpress.com/product_pic/hy-100187.gif)
HY-100187(Rac)-[6]-Gingerol -
Similarity Score 0.95
![[6]-Gingerol (Standard) Chemical Structure](//file.medchemexpress.com/product_pic/hy-14615r.gif)
HY-14615R[6]-Gingerol (Standard) -
Similarity Score 0.94
HY-N044810-Gingerol -
Similarity Score 0.94
HY-N0448A(±)-10-Gingerol -
Similarity Score 0.90
HY-N15732Methyl-8-gingerol -
Similarity Score 0.89
![5-Methoxy-[8]-gingerol Chemical Structure](//file.medchemexpress.com/product_pic/hy-n15733.gif)
HY-N157335-Methoxy-[8]-gingerol -
Similarity Score 0.88
HY-N168624-Gingerol -
Similarity Score 0.87
HY-N9947Methyl-6-gingerol -
Explore the MedChemAI to find more analogs
![(Rac)-[6]-Gingerol Chemical Structure](http://file.medchemexpress.com/product_pic/hy-100187.gif)
![[6]-Gingerol (Standard) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-14615r.gif)
![5-Methoxy-[8]-gingerol Chemical Structure](http://file.medchemexpress.com/product_pic/hy-n15733.gif)
