(±)-10-Gingerol 

(±)-10-Gingerol is the racemic form of 10-Gingerol (HY-N0448). 10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC₅₀ value of 10.47 μM against DPPH radical, an IC₅₀ value of 1.68 μM against superoxide radical and an IC₅₀ value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC₅₀ of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol can be used in research on various common cancers such as ovarian cancer and colon cancer, as well as colitis and neurodegenerative diseases^{[1][2][3][4][5]}.

(±)-10-Gingerol (29.19-50.87 μM) potently inhibits cervical cancer HeLa cells with an IC₅₀ of 29.19 μM and IC₈₀ of 50.87 μM by inducing G0/G1 phase cell cycle arrest and apoptosis^[1].
(±)-10-Gingerol (15.24-21.59 μM) potently inhibits LTA₄H aminopeptidase (IC₅₀ = 21.59 μM) and epoxide hydrolase (IC₅₀ = 15.24 μM) in human colon cancer HCT-116 cells, showing greater activity than other tested gingerols^[1].
(±)-10-Gingerol inhibits proliferation and invasion of human breast cancer MDA-MB-231 cells through inactivation of AKT and p38/MAPK signaling and suppression of epidermal growth factor receptor expression^[1].
(±)-10-Gingerol (30 μM) inhibits proliferation of human colon cancer HCT-116 cells and induces mitochondrial-mediated apoptosis via activation of the MAPK pathway^[1].
(±)-10-Gingerol (50 μM) inhibits growth of human prostate cancer PC-3 cells with an IC₅₀ of 50 μM (17.53 μg mL^-1)^[1].
(±)-10-Gingerol selectively induces cytotoxicity and reverts the malignant phenotype of T4-2 breast cancer cells in in vitro 3D culture, while sparing non-malignant HMT3522 S1 mammary epithelial cells^[1].
(±)-10-Gingerol shows greater cytotoxicity against human A549 lung adenocarcinoma, SK-OV-3 ovarian cancer, SK-MEL-2 skin melanoma, and HCT15 colon cancer cells than other tested gingerols^[1].
(±)-10-Gingerol (12.1 μM) potently inhibits growth of human triple-negative breast cancer MDA-MB-231 cells by inducing S-phase cell cycle arrest and mitochondrial-mediated apoptosis^[1].
(±)-10-Gingerol (10-100 μM) induces concentration-dependent cell death in human colorectal cancer SW480 cells by increasing intracellular calcium levels^[1].
(±)-10-Gingerol (20 μM) potently inhibits LPS-induced neuroinflammation in murine BV2 microglial cells by suppressing NF-κB activation and proinflammatory cytokine production, and is the primary contributor to fresh Zingiber officinale's anti-neuroinflammatory capacity^[1].
(±)-10-Gingerol (1.35-10.47 μM) is the most potent anti-oxidant among tested gingerols, with IC₅₀ values of 10.47 μM for DPPH radical scavenging, 1.68 μM for superoxide radical scavenging, and 1.35 μM for hydroxyl radical scavenging^[1].
(±)-10-Gingerol (4-50 μg mL^-1) exhibits potent anti-bacterial activity against periodontal bacteria, Mycobacterium species, and CagA+ Helicobacter pylori, with MIC ranges from 6.25-50 μg mL^-1 and MBC ranges from 4-20 μg mL^-1 for periodontal pathogens^[1].
(±)-10-Gingerol moderately inhibits the growth of human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells in vitro with ED₅₀ values of 5.09 μg/mL, 4.52 μg/mL, 5.92 μg/mL, and 6.57 μg/mL, respectively^[2].
(±)-10-Gingerol (5-20 μM; 20 h) dose-dependently inhibits LPS-induced NO production in BV2 microglial cells, with 84.1% inhibition at 20 μM^[4].
(±)-10-Gingerol (20 μM; 12 h (protein analysis); 6 h (mRNA analysis)) inhibits LPS-induced iNOS protein and mRNA expression in BV2 microglial cells, with 73.5% suppression of iNOS protein at 20 μM^[4].
(±)-10-Gingerol (20 μM; 20 h) inhibits LPS-induced TNF-α, IL-1β, and IL-6 secretion in BV2 microglial cells, with 72.1% inhibition of TNF-α, 55.9% inhibition of IL-1β, and potent inhibition of IL-6 at 20 μM^[4].
(±)-10-Gingerol (20 μM; 6 h) downregulates LPS-induced TNF-α, IL-1β, and IL-6 mRNA expression in BV2 microglial cells at 20 μM, with effects correlating closely with reduced cytokine secretion^[4].
(±)-10-Gingerol (20 μM; 1 h) moderately inhibits LPS-induced NF-κB DNA binding activity in BV2 microglial cells at 20 μM^[4].
(±)-10-Gingerol (12.5 μM; 20 h) inhibits LPS-induced NO production in BV2 microglial cells by 71.7%, and is the primary contributor to the NO-suppressing activity of fresh ginger ethanolic extract^[4].
(±)-10-Gingerol (12.5 μM; 12 h (protein analysis); 6 h (mRNA analysis)) inhibits LPS-induced iNOS protein expression by 61.0% and iNOS mRNA expression by 36.7% in BV2 microglial cells, and is the primary contributor to the iNOS-suppressing activity of fresh ginger ethanolic extract^[4].
(±)-10-Gingerol (12.5 μM; 20 h (cytokine secretion); 6 h (mRNA analysis)) inhibits LPS-induced TNF-α, IL-1β, and IL-6 secretion and mRNA expression in BV2 microglial cells, and is the primary contributor to the proinflammatory cytokine-suppressing activity of fresh ginger ethanolic extract^[4].
(±)-10-Gingerol (Multiple concentrations; 30 min) potently scavenges DPPH radicals with an IC₅₀ of 10.47 μM, and activity increases with higher concentrations^[5].
(±)-10-Gingerol (Multiple concentrations; first 1 min) potently scavenges superoxide radicals with an IC₅₀ of 1.68 μM, with activity increasing in a dose-dependent manner^[5].
(±)-10-Gingerol (Multiple concentrations; first 1 min) potently scavenges hydroxyl radicals with an IC₅₀ of 1.35 μM, with activity increasing in a dose-dependent manner^[5].
(±)-10-Gingerol (6 μM; 15 min pre-incubation, 10 min monitoring) significantly inhibits f-MLP-induced ROS production in human polymorphonuclear neutrophils^[5].
(±)-10-Gingerol (1-6 μM; 24 h) inhibits LPS-induced nitrite production in RAW 264.7 macrophages in a dose-dependent manner, achieving 75% inhibition at 6 μM without causing cytotoxicity^[5].
(±)-10-Gingerol (1-6 μM; 24 h) inhibits LPS-induced PGE₂ production in RAW 264.7 macrophages in a dose-dependent manner, achieving 73% inhibition at 6 μM^[5].
10-Gingerol (25 μg/mL) inhibits growth of Mycobacterium avium in vitro with a minimum inhibitory concentration of 25 μg/mL^[6].
10-Gingerol (50 μg/mL) inhibits growth of Mycobacterium tuberculosis in vitro with a minimum inhibitory concentration of 50 μg/mL^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(±)-10-Gingerol exhibits potent wound healing activity in Mus musculus with induced wounds^[1].
(±)-10-Gingerol promotes hematopoietic recovery in phenylhydrazone-induced anemic Danio rerio embryos^[1].
(±)-10-Gingerol stimulates hematopoiesis in normal zebrafish embryos^[1].
(±)-10-Gingerol (30 mg/kg; i.p.; daily; 7 days) exhibits strong efficacy in ameliorating dextran sulfate sodium-induced acute ulcerative colitis in rats via antioxidant and antiinflammatory activities, with potency comparable to related gingerol analogs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

350.49

C₂₁H₃₄O₄

107257-18-1

O=C(CC(CCCCCCCCC)O)CCC1=CC=C(C(OC)=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dugasani S, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20.  [Content Brief]

  [2]. Almada da Silva J, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62.  [Content Brief]

  [3]. Ediriweera MK, Moon JY, Nguyen YT, Cho SK. 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells. Molecules. 2020;25(14):3164.  [Content Brief]

  [4]. Zhang F, et al. Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats. Phytother Res. 2017 Sep;31(9):1427-1432.  [Content Brief]

  [5]. Deng B, et al. 10-Gingerol, a natural AMPK agonist, suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. Food Funct. 2022 Mar 21;13(6):3234-3246.  [Content Brief]