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gramines

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By Targets:	Adiponectin Receptor (1) Adrenergic Receptor (2) Drug Derivative (1) Drug Intermediate (1) Reference Standards (1) Reverse Transcriptase (3)
By Research Areas:	Cancer (2) Endocrinology (2) Infection (3) Metabolic Disease (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0166

*Gramine* 4 Publications Verification Donaxine	Adiponectin Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-33893

Indole-3-methanamine 2 Publications Verification	Drug Derivative Drug Intermediate	Infection
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .

HY-N0166R

Gramine (Standard) 4 Publications Verification Donaxine (Standard)	Reference Standards Adrenergic Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-N0166S

Gramine-d2 Donaxine-d₂	Adrenergic Receptor Reverse Transcriptase	Others
Gramine-d₂ is the deuterium labeled Gramine . Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0166

*Gramine* 4 Publications Verification Donaxine	Infection Alkaloids Structural Classification Classification of Application Fields Gramineae Metabolic Disease Plants Disease Research Fields Arundo donax Linn. Endocrinology Indole Alkaloids Source Classification	Adiponectin Receptor Reverse Transcriptase
Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-33893

Indole-3-methanamine 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Derivative Drug Intermediate
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .

HY-N0166R

Gramine (Standard) 4 Publications Verification Donaxine (Standard)	Infection Alkaloids Classification of Application Fields Gramineae Metabolic Disease Plants Disease Research Fields Arundo donax Linn. Endocrinology Source Classification	Reference Standards Adrenergic Receptor Reverse Transcriptase
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

Cat. No.	Product Name	Chemical Structure

HY-N0166S

Gramine-d2
Gramine-d₂ is the deuterium labeled Gramine . Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

Gramine-d2

Gramine-d₂ is the deuterium labeled Gramine . Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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gramines

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products