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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

hPADI4-stable mES cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Protein Arginine Deiminase (3)
By Research Areas:	Cancer (1) Inflammation/Immunology (2)

Inhibitors & Agonists

Peptides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P11869

PADI4_11	Protein Arginine Deiminase	Inflammation/Immunology
PADI4_11 is an isoform-selective, allosteric *PADI4* activator with a K_d of 457 nM. PADI4_11 enters cells via active transport, does not induce cytotoxicity or membrane damage, and serves as a tool for investigating the regulation, function and cellular reprogramming of *PADI4. PADI4*_11 can be used in studies related to rheumatoid arthritis and ulcerative colitis .

HY-P11870

PADI4_7	Protein Arginine Deiminase	Others
PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to *PADI4* but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular *PADI4* from cell extracts for biochemical analyses, including the identification of *PADI4*-interacting proteins under resting or activated conditions .

HY-P11868

PADI4_3	Protein Arginine Deiminase	Inflammation/Immunology Cancer
PADI4_3 is a substrate-competitive and selective PADI4 inhibitor with an IC₅₀ of 56 nM. PADI4_3 blocks citrullination of histone H3 and reduces the formation of neutrophil extracellular traps. PADI4_3 can be used in research related to autoimmune diseases and cancers .

Cat. No.	Product Name	Target	Research Area

HY-P11869

PADI4_11	Protein Arginine Deiminase	Inflammation/Immunology
PADI4_11 is an isoform-selective, allosteric *PADI4* activator with a K_d of 457 nM. PADI4_11 enters cells via active transport, does not induce cytotoxicity or membrane damage, and serves as a tool for investigating the regulation, function and cellular reprogramming of *PADI4. PADI4*_11 can be used in studies related to rheumatoid arthritis and ulcerative colitis .

HY-P11870

PADI4_7	Protein Arginine Deiminase	Others
PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to *PADI4* but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular *PADI4* from cell extracts for biochemical analyses, including the identification of *PADI4*-interacting proteins under resting or activated conditions .

HY-P11868

PADI4_3	Protein Arginine Deiminase	Inflammation/Immunology Cancer
PADI4_3 is a substrate-competitive and selective PADI4 inhibitor with an IC₅₀ of 56 nM. PADI4_3 blocks citrullination of histone H3 and reduces the formation of neutrophil extracellular traps. PADI4_3 can be used in research related to autoimmune diseases and cancers .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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