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Cat. No.: HY-P11870

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PADI4_7

PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to PADI4 but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular PADI4 from cell extracts for biochemical analyses, including the identification of PADI4-interacting proteins under resting or activated conditions.

For research use only. We do not sell to patients.

Formula: C₈₄H₁₁₀N₁₈O₁₉S
Molecular Weight:1707.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PADI4_7 Chemical Structure

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PADI4

8 nM (Kd)

In Vitro

PADI4_7 (30 μM) is an inert binder that does not modulate the catalytic activity of recombinant PADI4 in vitro^[1].
Biotinylated PADI4_7 (bio-PADI4_7) specifically enriches human PADI4 from lysates of mES cells stably expressing hPADI4, enabling the isolation of intracellular PADI4 for biochemical analysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1707.95
Formula C₈₄H₁₁₀N₁₈O₁₉S
SMILES

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CSC7)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC8=CC=C(C=C8)O)NC7=O
Sequence

{dTyr}-Tyr-Pro-Lys-Gly-Ser-Trp-Gly-Tyr-Lys-Leu-Phe-Cys-Gly-NH2 (thioether bond:dTyr1-Cys13)
Sequence Shortening

{dTyr}-YPKGSWGYKLFCG-NH2 (thioether bond:dTyr1-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bertran MT, et al. A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation. Nat Commun. 2024;15(1):9746. Published 2024 Nov 11. [Content Brief]

[2]. Bertran M T, et al. A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation[J]. BioRxiv, 2023: 2023.12. 12.571217.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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