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Results for "

heteroaryl

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

3

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148673
    Laroprovstat
    1 Publications Verification

    AZD0780; PCSK9-IN-12

    		 PCSK9 Cardiovascular Disease Metabolic Disease
    Laroprovstat (AZD0780) is an orall active PCSK9 inhibitor. PCSK9-IN-12 has bind affinity for PCSK9 with a Kd value of <200 nM. Laroprovstat binds to a pocket in the PCSK9 C-terminal domain and does not affect the PCSK9-LDL receptor (LDLR) interaction. Laroprovstat inhibits lysosomal trafficking of PSCK9-LDLR complexes and prevents PCSK9-induced LDLR degradation. Laroprovstat can be used for the research of hypercholesterolemia .
    Laroprovstat
  • HY-W002251
    Benzo[b]thiophene-3-carbaldehyde

    		Biochemical Assay Reagents Others
    Benzo[b]thiophene-3-carbaldehyde is a 3-formyl-substituted benzo[b]thiophene derivative that acts as an oxidizable substrate to convert to benzo[b]thiophene-3-carboxylic acid under liquid-phase conditions. Compared with analogs such as benzaldehyde and thiophene-2-carbaldehyde, Benzo[b]thiophene-3-carbaldehyde has lower oxidation difficulty, and can significantly increase the reaction rate in the presence of initiators (such as Na +Br - or DBA). Benzo[b]thiophene-3-carbaldehyde also serves as a key starting material for the synthesis of compounds including heteroaryl chalcones .
    Benzo[b]thiophene-3-carbaldehyde
  • HY-Y0373
    tert-Butyl carbazate

    		Biochemical Assay Reagents Drug Intermediate Infection
    tert-Butyl carbazate serves as a starting material for the preparation of heterocyclic and hydrazine derivatives. tert-Butyl carbazate undergoes coupling with aryl, heteroaryl, and alkenyl boronic acids to synthesize doubly protected monosubstituted hydrazines. Derivatives of tert-Butyl carbazate exhibit varying degrees of inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, and various fungi .
    tert-Butyl carbazate
  • HY-W002805
    2-Bromoisonicotinic acid
    1 Publications Verification

    		 Drug Intermediate Others
    2-Bromoisonicotinic acid is a (hetero)aryl bromide building block and DNA-conjugated headpiece for photochemical C-H heteroarylation in DNA-encoded library synthesis. 2-Bromoisonicotinic acid generates a nucleophilic pyridyl radical intermediate. 2-Bromoisonicotinic acid, when conjugated to DNA, leaves electrophilic handles intact for subsequent library diversification .
    2-Bromoisonicotinic acid
  • HY-19094
    DuP-532

    		Angiotensin Receptor Cardiovascular Disease
    DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction .
    DuP-532
  • HY-178769
    GLP-1R agonist 36

    		GLP Receptor Metabolic Disease
    GLP-1R agonist 36 (Compound 53) is a GLP-1R agonist with a total of four isomers. GLP-1R agonist 36 can be used for the studies of diabetes and obesity.
    GLP-1R agonist 36
  • HY-178768
    GLP-1R agonist 35

    		GLP Receptor Metabolic Disease
    GLP-1R agonist 35 (Compound 111-2) is a GLP-1R agonist with an EC50 of 0-10 nM. GLP-1R agonist 36 can be used for the studies of diabetes and obesity .
    GLP-1R agonist 35
  • HY-135830
    AHR antagonist 4

    		Aryl Hydrocarbon Receptor Cancer
    AHR antagonist 4 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 293, has an IC50 of 82.2 nM. AHR antagonist 4 has anti-cancer effects .
    AHR antagonist 4
  • HY-W001222
    3-Furanboronic acid

    		Biochemical Assay Reagents Others
    3-Furanboronic acid is a biochemical reagent. 3-Furanboronic acid can be smoothly coupled with a variety of active and inactive 2-chloropyridines, 2-chloroquinolines, and 2-chloropyrimidine .
    3-Furanboronic acid
  • HY-153592
    Therapeutic agent-1

    		Glycosidase Others
    Therapeutic agent-1 is a heteroaryl compound that can be used in Gaucher disease glucocerebrosidase activity enzyme replacement therapy .
    Therapeutic agent-1
  • HY-W684904
    LY550410

    		TGF-β Receptor Cancer
    LY550410 is a small-molecule ATP-competitive inhibitor against type I TGF-β receptor kinase, which contains heteroaryl rings for potent binding to the kinase-domain active site. LY550410 modulates TGF-β signalling, thereby regulates gene expression and ultimately cell growth. LY550410 is promising for research of cancers .
    LY550410
  • HY-143582
    ATX inhibitor 9

    		Phosphodiesterase (PDE) Cancer
    ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3) .
    ATX inhibitor 9

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