AHR antagonist 4
AHR antagonist 4 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 293, has an IC50 of 82.2 nM. AHR antagonist 4 has anti-cancer effects.
For research use only. We do not sell to patients.
- CAS No.: 2242465-58-1
- Formula: C20H14F6N4O4
- Molecular Weight:488.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
IC50: 82.2 nM (Aryl hydrocarbon receptor (AHR))[1]
Chemical Information
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CAS No. 2242465-58-1
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Molecular Weight 488.34
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Formula C20H14F6N4O4
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SMILES
O=C(C1=CC(C2=CC=C(OC(F)(F)F)C=C2)=NN(C3=CC=CN=C3)C1=O)NC[C@H](O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)