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irf4

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By Targets:	Apoptosis (3) c-Myc (1) CDK (1) DNA/RNA Synthesis (1) Epigenetic Reader Domain (1) Histone Acetyltransferase (1) Histone Methyltransferase (1) IFNAR (3) IKZF Family (1) Ligands for E3 Ligase (1) Molecular Glues (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (3)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130800

Eragidomide 5+ Cited Publications CC-90009	Ligands for E3 Ligase Molecular Glues Apoptosis	Inflammation/Immunology Cancer
Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4 ^CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation .

HY-172085

SH514	IFNAR DNA/RNA Synthesis c-Myc CDK	Cancer
SH514 is an orally active *IRF4* inhibitor (IC₅₀ = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors .

HY-177632

Frenlosirsen ION-935918; ION251	IFNAR	Cancer
Frenlosirsen is an antisense oligonucleotide targeted to IRF4. It is used for study of relapsed/refractory multiple myeloma (RRMM).

HY-RS16800

Irf4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Irf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irf4 Mouse Pre-designed siRNA Set A Irf4 Mouse Pre-designed siRNA Set A

HY-172614

RK-0080552 RK-552	Histone Methyltransferase Apoptosis	Cancer
RK-0080552 (RK-552) is a NSD2 inhibitor with an IC₅₀ of 0.11 μM, and it exhibits selectivity over histone methyltransferases G9a (IC₅₀: 1.2 μM) and SET7/9 (IC₅₀: >50 μM). RK-0080552 functionally inhibits NSD2 histone methyltransferase activity, reduces the dimethylation level of histone H3 lysine 36, suppresses *IRF4* transcription, induces apoptosis and triggers cell death. RK-0080552 inhibits the growth of xenograft tumors and prolongs host survival. RK-0080552 is available for the research of multiple myeloma .

HY-RS06908

IRF4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IRF4 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRF4 Human Pre-designed siRNA Set A IRF4 Human Pre-designed siRNA Set A

HY-RS23241

Irf4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Irf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irf4 Rat Pre-designed siRNA Set A Irf4 Rat Pre-designed siRNA Set A

HY-177632A

Frenlosirsen sodium ION-935918 sodium; ION251 sodium	IFNAR	Cancer
Frenlosirsen sodium is an antisense oligonucleotide targeted to IRF4. It is used for study of relapsed/refractory multiple myeloma (RRMM).

HY-181957

KB528	Epigenetic Reader Domain Histone Acetyltransferase Apoptosis IKZF Family	Cancer
KB528 is a p300/CBP histone acetyltransferase (KAT) inhibitor with low nM IC₅₀ values against human p300 and CBP, and exhibits selectivity over other KAT family members. KB528 modulates the *IRF4* transcriptional network, downregulates the expression of *IRF4, MYC, CAV2* and IGLL5, and reduces the protein level of IKZF3. KB528 potently induces apoptosis in multiple myeloma cells. KB528 is applicable to research related to multiple myeloma .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3)
Application:	IHC-P (3) ICC/IF (2) IP (1) WB (2) FC (1) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85920

	MUM1 Antibody (YA5612) Interferon regulatory factor 4; irf 4; irf-4; irf4; irf4_HUMAN; LSirf; Lymphocyte specific interferon regulatory factor; Lymphocyte specific irf; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM 1; MUM1; NF EM5; NF-EM5; NFEM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; Transcriptional activator PIP	IHC-P, WB, ICC/IF, ELISA	Human
	MUM1 Antibody (YA5612) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUM1.

HY-P82663

	MUM1 Antibody (YA2408) irf4; MUM1; Interferon regulatory factor 4; irf-4; Lymphocyte-specific interferon regulatory factor; LSirf; Multiple myeloma oncogene 1; NF-EM5	WB, IHC-P, ICC/IF, IP, FC	Human
	MUM1 Antibody (YA2408) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MUM1.

HY-P86042

	MUM1 Antibody (YA5734) Interferon regulatory factor 4; irf-4; Lymphocyte-specific interferon regulatory factor; LSirf; Multiple myeloma oncogene 1; NF-EM5;	IHC-P, ELISA	Human
	MUM1 Antibody (YA5734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUM1.

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Frenlosirsen ION-935918; ION251		Antisense Oligonucleotides
Frenlosirsen is an antisense oligonucleotide targeted to IRF4. It is used for study of relapsed/refractory multiple myeloma (RRMM).

Irf4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Irf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRF4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IRF4 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irf4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Irf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Frenlosirsen sodium ION-935918 sodium; ION251 sodium		Antisense Oligonucleotides
Frenlosirsen sodium is an antisense oligonucleotide targeted to IRF4. It is used for study of relapsed/refractory multiple myeloma (RRMM).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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